Transplantation outcome according to malignancy risk factors
Risk level§ . | UPN . | Age/sex . | Malignancy characteristics* . | GVHD† . | Overall outcome‡ . | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study entry . | Pre-HCT . | Acute . | Late acute . | Chronic . | ||||||||||||
Dx . | # . | Res . | Res . | NED . | s . | g . | l . | Gr . | Tumor . | Survival . | Death . | |||||
1 | 1 | 65/M | MCL | 2 | 1° R | PR | N | 0 | 0 | 0 | 0 | 0 | N | PD | N | 211 (PD) |
2 | 48/F | MDS | 2 | S | CR | Y | 0 | 0 | 0 | 0 | tr | Y (o, s) | CR | + 2566 | n.a. | |
10 | 35/F | FCL | 5 | S | PR | N | 0 | 0 | 0 | 0 | 0 | Y (o, s, e, v) | CR | N | 955 (PE) | |
12 | 66/M | MF | 1 | R | SD | N | 0 | 0 | 0 | 0 | 0 | N | CR | + 1696 | n.a. | |
13 | 59/M | MCL | 4 | S | CR | Y | 0 | 0 | 0 | 0 | g | Y (s, e, l) | CR | N | 1053 (MI) | |
17 | 65/F | FCL | 3 | S | SD | N | 0 | 0 | 0 | 0 | tr, g | Y (o, s, e) | CR | + 1717 | n.a. | |
18 | 37/M | FCL | 3 | 1° R | PR | N | 0 | 0 | 0 | 0 | 0 | Y (o) | CR | + 1598 | n.a. | |
20 | 60/M | MCL | 3 | S | CR | Y | 0 | 0 | 0 | 0 | 0 | N | CR | + 1514 | n.a. | |
35 | 53/M | MCL | 2 | 1° R | SD | N | 0 | 0 | 0 | 0 | tr | N | CR | + 1312 | n.a. | |
2 | 5 | 39/F | CML | 1 | S | hCR | N | 0 | 0 | 0 | 0 | tr | Y (e) | mCR | + 2468 | n.a. |
8 | 55/M | CLL | 3 | S | PR | N | 3 | 0 | 0 | 2 | tr, s | N | PD | N | 772 (PD) | |
11 | 50/F | MM | 2 | R | SD | N | 0 | 0 | 0 | 0 | tr | Y (s) | SD | + 1710 | n.a. | |
22 | 63/M | CLL | 5 | R | SD | N | 0 | 0 | 0 | 0 | 0 | N | PD | N | 911 (PD) | |
30 | 55/F | MDS | 1 | S | SD | N | 0 | 0 | 0 | 0 | 0 | N | PD | + 1340 | n.a. | |
32 | 66/F | MM | 1 | 1° R | SD | N | 3 | 1 | 0 | 2 | tr | Y (s, o, e) | CR | + 1356 | n.a. | |
33 | 63/M | CLL | 2 | S | SD | N | 0 | 0 | 0 | 0 | 0 | Y (o, s) | CR | + 1326 | n.a. |
Risk level§ . | UPN . | Age/sex . | Malignancy characteristics* . | GVHD† . | Overall outcome‡ . | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study entry . | Pre-HCT . | Acute . | Late acute . | Chronic . | ||||||||||||
Dx . | # . | Res . | Res . | NED . | s . | g . | l . | Gr . | Tumor . | Survival . | Death . | |||||
1 | 1 | 65/M | MCL | 2 | 1° R | PR | N | 0 | 0 | 0 | 0 | 0 | N | PD | N | 211 (PD) |
2 | 48/F | MDS | 2 | S | CR | Y | 0 | 0 | 0 | 0 | tr | Y (o, s) | CR | + 2566 | n.a. | |
10 | 35/F | FCL | 5 | S | PR | N | 0 | 0 | 0 | 0 | 0 | Y (o, s, e, v) | CR | N | 955 (PE) | |
12 | 66/M | MF | 1 | R | SD | N | 0 | 0 | 0 | 0 | 0 | N | CR | + 1696 | n.a. | |
13 | 59/M | MCL | 4 | S | CR | Y | 0 | 0 | 0 | 0 | g | Y (s, e, l) | CR | N | 1053 (MI) | |
17 | 65/F | FCL | 3 | S | SD | N | 0 | 0 | 0 | 0 | tr, g | Y (o, s, e) | CR | + 1717 | n.a. | |
18 | 37/M | FCL | 3 | 1° R | PR | N | 0 | 0 | 0 | 0 | 0 | Y (o) | CR | + 1598 | n.a. | |
20 | 60/M | MCL | 3 | S | CR | Y | 0 | 0 | 0 | 0 | 0 | N | CR | + 1514 | n.a. | |
35 | 53/M | MCL | 2 | 1° R | SD | N | 0 | 0 | 0 | 0 | tr | N | CR | + 1312 | n.a. | |
2 | 5 | 39/F | CML | 1 | S | hCR | N | 0 | 0 | 0 | 0 | tr | Y (e) | mCR | + 2468 | n.a. |
8 | 55/M | CLL | 3 | S | PR | N | 3 | 0 | 0 | 2 | tr, s | N | PD | N | 772 (PD) | |
11 | 50/F | MM | 2 | R | SD | N | 0 | 0 | 0 | 0 | tr | Y (s) | SD | + 1710 | n.a. | |
22 | 63/M | CLL | 5 | R | SD | N | 0 | 0 | 0 | 0 | 0 | N | PD | N | 911 (PD) | |
30 | 55/F | MDS | 1 | S | SD | N | 0 | 0 | 0 | 0 | 0 | N | PD | + 1340 | n.a. | |
32 | 66/F | MM | 1 | 1° R | SD | N | 3 | 1 | 0 | 2 | tr | Y (s, o, e) | CR | + 1356 | n.a. | |
33 | 63/M | CLL | 2 | S | SD | N | 0 | 0 | 0 | 0 | 0 | Y (o, s) | CR | + 1326 | n.a. |
CLL, chronic lymphocytic leukemia; Dx, diagnoses; F, female; FCL, follicular non-Hodgkin lymphoma; M, male; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MF, myelofibrosis; MM, multiple myeloma; N, no; n.a., not applicable; NED, no evidence of disease status; UPN, unique patient number; Y, yes.
#, number of prior regimens. Res, disease response: 1° R, primary refractory; S, sensitive to last regimen; and R, refractory to last regimen. Pre-HCT, indicates disease status at time of low-intensity transplant: Res, response to EPOCH-F(R): PR, partial response; CR, complete response; SD, stable disease; and hCR, hematologic CR.
Acute GVHD score of skin (s), gut (g), and liver (l); Gr, overall grade (0-4). Late acute GVHD, manifested as elevated liver transaminase levels (tr), skin (s), or gut involvement (g). Chronic GVHD sites of involvement: oral (o), skin (s), eye (e), vaginal (v), and lung (l).
Overall outcome for last tumor staging: PD, progressive disease; CR, complete remission; mCR, molecular CR; and SD, stable disease. Ongoing survival, in days post-HCT (+). Death, day post-HCT; cause due to PD, presumed pulmonary embolus (PE), or myocardial infarction (MI).
Risk of progressive disease post-HCT: level 1, low risk; level 2, standard risk.