Table 1

Transplantation outcome according to malignancy risk factors

Risk level§UPNAge/sexMalignancy characteristics*GVHDOverall outcome
Study entryPre-HCTAcuteLate acuteChronic
Dx#ResResNEDsglGrTumorSurvivalDeath
65/M MCL 1° R PR PD 211 (PD) 
 48/F MDS CR tr Y (o, s) CR + 2566 n.a. 
 10 35/F FCL PR Y (o, s, e, v) CR 955 (PE) 
 12 66/M MF SD CR + 1696 n.a. 
 13 59/M MCL CR Y (s, e, l) CR 1053 (MI) 
 17 65/F FCL SD tr, g Y (o, s, e) CR + 1717 n.a. 
 18 37/M FCL 1° R PR Y (o) CR + 1598 n.a. 
 20 60/M MCL CR CR + 1514 n.a. 
 35 53/M MCL 1° R SD tr CR + 1312 n.a. 
39/F CML hCR tr Y (e) mCR + 2468 n.a. 
 55/M CLL PR tr, s PD 772 (PD) 
 11 50/F MM SD tr Y (s) SD + 1710 n.a. 
 22 63/M CLL SD PD 911 (PD) 
 30 55/F MDS SD PD + 1340 n.a. 
 32 66/F MM 1° R SD tr Y (s, o, e) CR + 1356 n.a. 
 33 63/M CLL SD Y (o, s) CR + 1326 n.a. 
Risk level§UPNAge/sexMalignancy characteristics*GVHDOverall outcome
Study entryPre-HCTAcuteLate acuteChronic
Dx#ResResNEDsglGrTumorSurvivalDeath
65/M MCL 1° R PR PD 211 (PD) 
 48/F MDS CR tr Y (o, s) CR + 2566 n.a. 
 10 35/F FCL PR Y (o, s, e, v) CR 955 (PE) 
 12 66/M MF SD CR + 1696 n.a. 
 13 59/M MCL CR Y (s, e, l) CR 1053 (MI) 
 17 65/F FCL SD tr, g Y (o, s, e) CR + 1717 n.a. 
 18 37/M FCL 1° R PR Y (o) CR + 1598 n.a. 
 20 60/M MCL CR CR + 1514 n.a. 
 35 53/M MCL 1° R SD tr CR + 1312 n.a. 
39/F CML hCR tr Y (e) mCR + 2468 n.a. 
 55/M CLL PR tr, s PD 772 (PD) 
 11 50/F MM SD tr Y (s) SD + 1710 n.a. 
 22 63/M CLL SD PD 911 (PD) 
 30 55/F MDS SD PD + 1340 n.a. 
 32 66/F MM 1° R SD tr Y (s, o, e) CR + 1356 n.a. 
 33 63/M CLL SD Y (o, s) CR + 1326 n.a. 

CLL, chronic lymphocytic leukemia; Dx, diagnoses; F, female; FCL, follicular non-Hodgkin lymphoma; M, male; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MF, myelofibrosis; MM, multiple myeloma; N, no; n.a., not applicable; NED, no evidence of disease status; UPN, unique patient number; Y, yes.

*

#, number of prior regimens. Res, disease response: 1° R, primary refractory; S, sensitive to last regimen; and R, refractory to last regimen. Pre-HCT, indicates disease status at time of low-intensity transplant: Res, response to EPOCH-F(R): PR, partial response; CR, complete response; SD, stable disease; and hCR, hematologic CR.

Acute GVHD score of skin (s), gut (g), and liver (l); Gr, overall grade (0-4). Late acute GVHD, manifested as elevated liver transaminase levels (tr), skin (s), or gut involvement (g). Chronic GVHD sites of involvement: oral (o), skin (s), eye (e), vaginal (v), and lung (l).

Overall outcome for last tumor staging: PD, progressive disease; CR, complete remission; mCR, molecular CR; and SD, stable disease. Ongoing survival, in days post-HCT (+). Death, day post-HCT; cause due to PD, presumed pulmonary embolus (PE), or myocardial infarction (MI).

§

Risk of progressive disease post-HCT: level 1, low risk; level 2, standard risk.

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