Table 1 DC subsets and their properties... | American Society of Hematology

Table 1

DC subsets and their properties are grouped by the most prominently associated induced T-cell response

Immune response	DC subset	Uptake receptor	TLR	Cross-presentation	Comments
Th1	BDCA3^{+ H} CD8α^{+ M}	Clec9A, Langerin^M, DEC-205, Clec12A, DCAR1^M	1, 2, 3, 4^M, 6, 8, 9^M	++	Treg⁴⁷
	Langerhans	Langerin, DEC-205, Dectin1, Dectin2, DCIR^H	1^H, 2, 3, 4^M, 6^H,M?, 9^M	+	CTL induction or licensing⁹⁷ Th2, Th17, Th22
	Dermal CD1a^{+ H} Dermal CD103^{+ M}	Langerin, DEC-205, MGL^H, DCIR^H	3^M, 4^H	++	Th17⁹⁸
Th2	BDCA1^{+ H} CD8α^{− M}	DCIR2^M, Clec12A, DCIR, Dectin-1^H, DEC-205^H, mMGL1^M, 2^M,	1, 2, 3^H, 4, 5, 6, 7, 8, 9^M	+
Th1/Th2	moDC^H	DC-SIGN, DEC-205, MR, DCIR	1, 2, 3, 4, 5, 6, 8, 10	++	Th17
IFN-I	pDC	Siglec-H, BST-2, BDCA-2^H, Clec9A^M, Clec12A, Dectin-2, DEC-205^H, DCIR^H, Dectin-1^M, mMGL1^M	1^H,M?, 6^H,M?, 7, 9	+	Activation of myeloid DC and NK, B and T cells

Immune response	DC subset	Uptake receptor	TLR	Cross-presentation	Comments
Th1	BDCA3^{+ H} CD8α^{+ M}	Clec9A, Langerin^M, DEC-205, Clec12A, DCAR1^M	1, 2, 3, 4^M, 6, 8, 9^M	++	Treg⁴⁷
	Langerhans	Langerin, DEC-205, Dectin1, Dectin2, DCIR^H	1^H, 2, 3, 4^M, 6^H,M?, 9^M	+	CTL induction or licensing⁹⁷ Th2, Th17, Th22
	Dermal CD1a^{+ H} Dermal CD103^{+ M}	Langerin, DEC-205, MGL^H, DCIR^H	3^M, 4^H	++	Th17⁹⁸
Th2	BDCA1^{+ H} CD8α^{− M}	DCIR2^M, Clec12A, DCIR, Dectin-1^H, DEC-205^H, mMGL1^M, 2^M,	1, 2, 3^H, 4, 5, 6, 7, 8, 9^M	+
Th1/Th2	moDC^H	DC-SIGN, DEC-205, MR, DCIR	1, 2, 3, 4, 5, 6, 8, 10	++	Th17
IFN-I	pDC	Siglec-H, BST-2, BDCA-2^H, Clec9A^M, Clec12A, Dectin-2, DEC-205^H, DCIR^H, Dectin-1^M, mMGL1^M	1^H,M?, 6^H,M?, 7, 9	+	Activation of myeloid DC and NK, B and T cells

Expression of uptake receptors and TLRs as well as cross-presentation potential is of further importance in the choice of suitable targets. M, mouse; H, human

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