Patient/disease-specific characteristics and outcome by FAB category
| . | M0 . | M1 . | M2 . | M4 . | M5 . | M6 . | M7 . | . |
|---|---|---|---|---|---|---|---|---|
| Parameter . | n = 353 . | n = 1442 . | n = 1658 . | n = 1244 . | n = 868 . | n = 241 . | n = 42 . | P value* . |
| Age in y, median (range) | 60 (16-86) | 55 (14-86) | 54 (16-91) | 52 (16-88) | 52 (12-86) | 52 (16-87) | 50 (21-84) | < .001 |
| Patients aged ≥60 y, n (%) | 182 (52) | 568 (39) | 588 (35) | 391 (31) | 252 (29) | 73 (30) | 12 (29) | < .001 |
| Male gender, n (%) | 209 (59) | 762 (53) | 835 (50) | 621 (50) | 432 (50) | 153 (63) | 20 (48) | < .001 |
| Abnormal karyotype,† n (%) | 155 (44) | 442 (31) | 470 (28) | 349 (28) | 261 (30) | 69 (29) | 14 (33) | < .001 |
| NPM1 mutation,† n (%) | ||||||||
| Yes | 13 (11) | 234 (41) | 231 (40) | 245 (50) | 237 (60) | 20 (24) | 7 (50) | < .001 |
| No | 110 (89) | 336 (59) | 353 (60) | 249 (50) | 159 (40) | 63 (76) | 7 (50) | |
| Unknown | 230 | 872 | 1074 | 750 | 472 | 158 | 28 | |
| CEBPA mutation,† n (%) | ||||||||
| Yes | 5 (7) | 50 (13) | 54 (13) | 26 (8) | 14 (5) | 4 (7) | 1 (11) | < .001 |
| No | 71 (93) | 325 (87) | 361 (87) | 294 (92) | 282 (95) | 51 (93) | 8 (89) | |
| Unknown | 277 | 1067 | 1243 | 924 | 572 | 186 | 33 | |
| WBC† [×103/µL], median (range) | 5 (0-559) | 12 (0-435) | 9 (0-1100) | 26 (0-1300) | 39 (0-1104) | 2 (0-169) | 4 (1-35) | < .001 |
| Platelets† [×103/µL], median (range) | 66 (4-358) | 59 (2-7900) | 59 (0-1052) | 64 (0-5300) | 73 (1-9300) | 48 (0-335) | 61 (7-481) | < .001 |
| Bone marrow blasts,† median % (range) | 80 (0-100) | 86 (0-100) | 60 (0-100) | 70 (0-100) | 82 (0-100) | 24 (2-95) | 56 (0-99) | < .001 |
| PS,† n (%) | ||||||||
| 0 | 153 (43) | 640 (44) | 762 (46) | 475 (38) | 325 (37) | 125 (52) | 14 (33) | < .001 |
| 1 | 149 (42) | 572 (40) | 641 (39) | 473 (38) | 354 (41) | 85 (35) | 19 (45) | |
| ≥2 | 51 (14) | 230 (16) | 225 (15) | 296 (24) | 189 (22) | 31 (13) | 9 (21) | |
| CR, n (%) | 221 (63) | 1072 (74) | 1301 (78) | 946 (76) | 697 (80) | 196 (81) | 27 (64) | < .001 |
| Early death,‡ n (%) | 29 (8) | 119 (8) | 84 (5) | 92 (7) | 80 (9) | 6 (2) | 1 (2) | < .001 |
| . | M0 . | M1 . | M2 . | M4 . | M5 . | M6 . | M7 . | . |
|---|---|---|---|---|---|---|---|---|
| Parameter . | n = 353 . | n = 1442 . | n = 1658 . | n = 1244 . | n = 868 . | n = 241 . | n = 42 . | P value* . |
| Age in y, median (range) | 60 (16-86) | 55 (14-86) | 54 (16-91) | 52 (16-88) | 52 (12-86) | 52 (16-87) | 50 (21-84) | < .001 |
| Patients aged ≥60 y, n (%) | 182 (52) | 568 (39) | 588 (35) | 391 (31) | 252 (29) | 73 (30) | 12 (29) | < .001 |
| Male gender, n (%) | 209 (59) | 762 (53) | 835 (50) | 621 (50) | 432 (50) | 153 (63) | 20 (48) | < .001 |
| Abnormal karyotype,† n (%) | 155 (44) | 442 (31) | 470 (28) | 349 (28) | 261 (30) | 69 (29) | 14 (33) | < .001 |
| NPM1 mutation,† n (%) | ||||||||
| Yes | 13 (11) | 234 (41) | 231 (40) | 245 (50) | 237 (60) | 20 (24) | 7 (50) | < .001 |
| No | 110 (89) | 336 (59) | 353 (60) | 249 (50) | 159 (40) | 63 (76) | 7 (50) | |
| Unknown | 230 | 872 | 1074 | 750 | 472 | 158 | 28 | |
| CEBPA mutation,† n (%) | ||||||||
| Yes | 5 (7) | 50 (13) | 54 (13) | 26 (8) | 14 (5) | 4 (7) | 1 (11) | < .001 |
| No | 71 (93) | 325 (87) | 361 (87) | 294 (92) | 282 (95) | 51 (93) | 8 (89) | |
| Unknown | 277 | 1067 | 1243 | 924 | 572 | 186 | 33 | |
| WBC† [×103/µL], median (range) | 5 (0-559) | 12 (0-435) | 9 (0-1100) | 26 (0-1300) | 39 (0-1104) | 2 (0-169) | 4 (1-35) | < .001 |
| Platelets† [×103/µL], median (range) | 66 (4-358) | 59 (2-7900) | 59 (0-1052) | 64 (0-5300) | 73 (1-9300) | 48 (0-335) | 61 (7-481) | < .001 |
| Bone marrow blasts,† median % (range) | 80 (0-100) | 86 (0-100) | 60 (0-100) | 70 (0-100) | 82 (0-100) | 24 (2-95) | 56 (0-99) | < .001 |
| PS,† n (%) | ||||||||
| 0 | 153 (43) | 640 (44) | 762 (46) | 475 (38) | 325 (37) | 125 (52) | 14 (33) | < .001 |
| 1 | 149 (42) | 572 (40) | 641 (39) | 473 (38) | 354 (41) | 85 (35) | 19 (45) | |
| ≥2 | 51 (14) | 230 (16) | 225 (15) | 296 (24) | 189 (22) | 31 (13) | 9 (21) | |
| CR, n (%) | 221 (63) | 1072 (74) | 1301 (78) | 946 (76) | 697 (80) | 196 (81) | 27 (64) | < .001 |
| Early death,‡ n (%) | 29 (8) | 119 (8) | 84 (5) | 92 (7) | 80 (9) | 6 (2) | 1 (2) | < .001 |