Characteristics of study population
| . | HOVON . | MDA . | MRC/NCRI . | SWOG . | All . |
|---|---|---|---|---|---|
| Parameter . | n = 578 . | n = 1003 . | n = 3666 . | n = 601 . | n = 5848 . |
| Age in y, median (range) | 48 (16-77) | 58 (12-88) | 54 (16-91) | 53 (16-84) | 54 (12-91) |
| Patients aged ≥60 y, n (%) | 44 (8) | 466 (46) | 1364 (37) | 192 (32) | 2066 (35) |
| Male gender, n (%) | 300 (52) | 534 (53) | 1879 (51) | 319 (53) | 3032 (52) |
| Karyotype,* n (%) | |||||
| Normal | 451 (78) | 456 (45) | 2749 (75) | 432 (72) | 4088 (70) |
| Abnormal | 127 (22) | 547 (55) | 917 (25) | 169 (28) | 1760 (30) |
| NPM1 mutation,* n (%) | |||||
| Yes | 293 (51) | 97 (26) | 520 (50) | 77 (28) | 987 (44) |
| No | 278 (49) | 275 (74) | 525 (50) | 199 (72) | 1277 (56) |
| Unknown | 7 | 631 | 2621 | 325 | 3584 |
| CEBPA mutation,* n (%) | |||||
| Yes | 61 (11) | 10 (12) | 42 (5) | 41 (48) | 154 (10) |
| No | 500 (89) | 76 (88) | 771 (95) | 45 (52) | 1392 (90) |
| Unknown | 17 | 917 | 2853 | 515 | 4302 |
| WBC* [×103/µL], median (range) | 29 (0-510) | 7 (0-390) | 15 (0-559) | 17 (0-1300) | 13 (0-1300) |
| Platelets* [×103/µL], median (range) | 69 (5-778) | 49 (0-635) | 65 (0-903) | 58 (3-9300) | 62 (0-9300) |
| Bone marrow blasts,* median % (range) | 68 (0-98) | 58 (0-99) | 80 (0-100) | 70 (1-100) | 73 (0-100) |
| FAB subclassification,* n (%) | |||||
| M0 | 28 (5) | 76 (8) | 215 (6) | 34 (6) | 353 (6) |
| M1 | 151 (26) | 162 (16) | 977 (27) | 152 (25) | 1442 (25) |
| M2 | 158 (27) | 340 (34) | 999 (27) | 161 (27) | 1658 (28) |
| M4 | 74 (13) | 244 (24) | 766 (21) | 160 (27) | 1244 (21) |
| M5 | 148 (26) | 116 (12) | 523 (14) | 81 (13) | 868 (15) |
| M6 | 19 (3) | 55 (5) | 158 (4) | 9 (1) | 241 (4) |
| M7 | 0 (0) | 10 (1) | 28 (1) | 4 (1) | 42 (1) |
| PS,* n (%) | |||||
| 0 | 250 (43) | 172 (17) | 1841 (50) | 231 (38) | 2494 (43) |
| 1 | 279 (48) | 628 (63) | 1090 (30) | 296 (49) | 2293 (39) |
| ≥2 | 49 (8) | 203 (20) | 735 (20) | 74 (12) | 1061 (18) |
| CR, n (%) | 499 (86) | 649 (65) | 2929 (80) | 383 (64) | 4460 (76) |
| Early death,† n (%) | 19 (3) | 55 (5) | 300 (8) | 37 (6) | 411 (7) |
| . | HOVON . | MDA . | MRC/NCRI . | SWOG . | All . |
|---|---|---|---|---|---|
| Parameter . | n = 578 . | n = 1003 . | n = 3666 . | n = 601 . | n = 5848 . |
| Age in y, median (range) | 48 (16-77) | 58 (12-88) | 54 (16-91) | 53 (16-84) | 54 (12-91) |
| Patients aged ≥60 y, n (%) | 44 (8) | 466 (46) | 1364 (37) | 192 (32) | 2066 (35) |
| Male gender, n (%) | 300 (52) | 534 (53) | 1879 (51) | 319 (53) | 3032 (52) |
| Karyotype,* n (%) | |||||
| Normal | 451 (78) | 456 (45) | 2749 (75) | 432 (72) | 4088 (70) |
| Abnormal | 127 (22) | 547 (55) | 917 (25) | 169 (28) | 1760 (30) |
| NPM1 mutation,* n (%) | |||||
| Yes | 293 (51) | 97 (26) | 520 (50) | 77 (28) | 987 (44) |
| No | 278 (49) | 275 (74) | 525 (50) | 199 (72) | 1277 (56) |
| Unknown | 7 | 631 | 2621 | 325 | 3584 |
| CEBPA mutation,* n (%) | |||||
| Yes | 61 (11) | 10 (12) | 42 (5) | 41 (48) | 154 (10) |
| No | 500 (89) | 76 (88) | 771 (95) | 45 (52) | 1392 (90) |
| Unknown | 17 | 917 | 2853 | 515 | 4302 |
| WBC* [×103/µL], median (range) | 29 (0-510) | 7 (0-390) | 15 (0-559) | 17 (0-1300) | 13 (0-1300) |
| Platelets* [×103/µL], median (range) | 69 (5-778) | 49 (0-635) | 65 (0-903) | 58 (3-9300) | 62 (0-9300) |
| Bone marrow blasts,* median % (range) | 68 (0-98) | 58 (0-99) | 80 (0-100) | 70 (1-100) | 73 (0-100) |
| FAB subclassification,* n (%) | |||||
| M0 | 28 (5) | 76 (8) | 215 (6) | 34 (6) | 353 (6) |
| M1 | 151 (26) | 162 (16) | 977 (27) | 152 (25) | 1442 (25) |
| M2 | 158 (27) | 340 (34) | 999 (27) | 161 (27) | 1658 (28) |
| M4 | 74 (13) | 244 (24) | 766 (21) | 160 (27) | 1244 (21) |
| M5 | 148 (26) | 116 (12) | 523 (14) | 81 (13) | 868 (15) |
| M6 | 19 (3) | 55 (5) | 158 (4) | 9 (1) | 241 (4) |
| M7 | 0 (0) | 10 (1) | 28 (1) | 4 (1) | 42 (1) |
| PS,* n (%) | |||||
| 0 | 250 (43) | 172 (17) | 1841 (50) | 231 (38) | 2494 (43) |
| 1 | 279 (48) | 628 (63) | 1090 (30) | 296 (49) | 2293 (39) |
| ≥2 | 49 (8) | 203 (20) | 735 (20) | 74 (12) | 1061 (18) |
| CR, n (%) | 499 (86) | 649 (65) | 2929 (80) | 383 (64) | 4460 (76) |
| Early death,† n (%) | 19 (3) | 55 (5) | 300 (8) | 37 (6) | 411 (7) |