Table 1

Definition of bleeding manifestations based on physical examination

Site of bleedingManifestationDefinition
Skin (epidermis and dermis)   
 Petechiae Red (recent) or purplish (a few days old) discoloration in the skin with a diameter of 0.5-3 mm that does not blanche with pressure and is not palpable 
 Ecchymosis (purpuric macule, bruises, or contusions) Flat, rounded, or irregular red, blue, purplish, or yellowish green patch, larger than a petechia. Elevation indicated spreading of an underlying hematoma into the superficial layers of the skin 
Skin (subcutaneous tissue)   
 Hematoma Bulging localized accumulation of blood, often with discoloration of overlying skin 
Visible mucous membranes   
 Petechiae, purpuric macules, and ecchymosis Same as for skin 
 Bulla, vesicle, and blister Visible raised, thin-walled, circumscribed lesion containing blood. Each bulla (>5 mm) is larger than a vesicle. Bullae, vesicles, and blisters should be counted together as bulla 
 Epistaxis Any bleeding from the nose may be anterior or posterior and unilateral or bilateral 
 Gingival bleeding Any bleeding from the gingival margins 
 Subconjunctival hemorrhage Bright red discoloration underneath the conjunctiva at onset; may assume the appearance of an ecchymosis over time 
Muscles and soft tissues   
 Hematoma Any localized collection of blood visible, palpable, or revealed by imaging. May dissect through fascial planes 
Site of bleedingManifestationDefinition
Skin (epidermis and dermis)   
 Petechiae Red (recent) or purplish (a few days old) discoloration in the skin with a diameter of 0.5-3 mm that does not blanche with pressure and is not palpable 
 Ecchymosis (purpuric macule, bruises, or contusions) Flat, rounded, or irregular red, blue, purplish, or yellowish green patch, larger than a petechia. Elevation indicated spreading of an underlying hematoma into the superficial layers of the skin 
Skin (subcutaneous tissue)   
 Hematoma Bulging localized accumulation of blood, often with discoloration of overlying skin 
Visible mucous membranes   
 Petechiae, purpuric macules, and ecchymosis Same as for skin 
 Bulla, vesicle, and blister Visible raised, thin-walled, circumscribed lesion containing blood. Each bulla (>5 mm) is larger than a vesicle. Bullae, vesicles, and blisters should be counted together as bulla 
 Epistaxis Any bleeding from the nose may be anterior or posterior and unilateral or bilateral 
 Gingival bleeding Any bleeding from the gingival margins 
 Subconjunctival hemorrhage Bright red discoloration underneath the conjunctiva at onset; may assume the appearance of an ecchymosis over time 
Muscles and soft tissues   
 Hematoma Any localized collection of blood visible, palpable, or revealed by imaging. May dissect through fascial planes 
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