Results of multivariate Cox model either in patients (N = 398) with karyotype and DNA index assessed (model 1) or in all patients (N = 446) with a karyotype assessed (models 2, 3, and 4)
| . | HR (95% CI) . | P value* . |
|---|---|---|
| Model 1 (number of EFS events = 40) | ||
| MNC: 54-57 vs 51-53 | 0.42 (0.21, 0.88) | .02 |
| MNC: 58-66 vs 51-53 | 0.04 (0.004, 0.37) | .004 |
| DI: 0 = DI <1.16; 1 = DI 1.16 to <1.24; 2 = DI ≥ 1.24 | 1.14 (0.62, 2.07) | .68 |
| Model 2 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.27, 0.93) | .03 |
| MNC: 58-66 vs 51-53 | 0.04 (0.006, 0.33) | .003 |
| WBC: 10 to <25 vs <10 × 109 per liter | 1.41 (0.66, 2.98) | .38 |
| WBC: ≥25 vs <10 × 109 per liter | 0.86 (0.36, 2.07) | .73 |
| Model 3 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.26, 0.94) | .03 |
| MNC: 58-66 vs 51-53 | 0.05 (0.006, 0.36) | .003 |
| EORTC risk group: AR low vs VLR | 0.96 (0.49, 1.88) | .91 |
| EORTC risk group: AR high vs VLR | 0.48 (0.064, 3.65) | .48 |
| EORTC risk group: VHR vs VLR | 1.97 (0.712, 5.45) | .19 |
| Model 4 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.27, 0.94) | .03 |
| MNC: 58-66 vs 51-53 | 0.05 (0.006, 0.35) | .003 |
| MRD: 10−3 to <10−2 vs undetectable | 1.73 (0.60, 4.97) | .31 |
| MRD: ≥10−2 vs undetectable | 4.03 (1.40, 11.6) | .01 |
| MRD: unknown vs undetectable | 2.39 (1.12, 11.4) | .02 |
| . | HR (95% CI) . | P value* . |
|---|---|---|
| Model 1 (number of EFS events = 40) | ||
| MNC: 54-57 vs 51-53 | 0.42 (0.21, 0.88) | .02 |
| MNC: 58-66 vs 51-53 | 0.04 (0.004, 0.37) | .004 |
| DI: 0 = DI <1.16; 1 = DI 1.16 to <1.24; 2 = DI ≥ 1.24 | 1.14 (0.62, 2.07) | .68 |
| Model 2 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.27, 0.93) | .03 |
| MNC: 58-66 vs 51-53 | 0.04 (0.006, 0.33) | .003 |
| WBC: 10 to <25 vs <10 × 109 per liter | 1.41 (0.66, 2.98) | .38 |
| WBC: ≥25 vs <10 × 109 per liter | 0.86 (0.36, 2.07) | .73 |
| Model 3 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.26, 0.94) | .03 |
| MNC: 58-66 vs 51-53 | 0.05 (0.006, 0.36) | .003 |
| EORTC risk group: AR low vs VLR | 0.96 (0.49, 1.88) | .91 |
| EORTC risk group: AR high vs VLR | 0.48 (0.064, 3.65) | .48 |
| EORTC risk group: VHR vs VLR | 1.97 (0.712, 5.45) | .19 |
| Model 4 | ||
| MNC: 54-57 vs 51-53 | 0.50 (0.27, 0.94) | .03 |
| MNC: 58-66 vs 51-53 | 0.05 (0.006, 0.35) | .003 |
| MRD: 10−3 to <10−2 vs undetectable | 1.73 (0.60, 4.97) | .31 |
| MRD: ≥10−2 vs undetectable | 4.03 (1.40, 11.6) | .01 |
| MRD: unknown vs undetectable | 2.39 (1.12, 11.4) | .02 |
Wald test.