Summary of model predictions for 51 considered patients from the IRIS trial (training set)/31 patients from the CML IV trial (validation set)
| Time to complete eradication of MRD | 48.9 y (28-112)/32.8 y (18-176) |
| Treatment time to 4.0 log reduction (MR4.0) | 6.5 y (5.0-9.7)/5.3 y (4.5-9.2) |
| Treatment time to 4.5 log reduction (MR4.5) | 10.7 y (7.7-13)/9.1 y (6.9-13) |
| Cumulative cure rate after 15 y of treatment | 14%/16% |
| Cumulative cure rate after 30 y of treatment | 31%/42% |
| Time to complete eradication of MRD | 48.9 y (28-112)/32.8 y (18-176) |
| Treatment time to 4.0 log reduction (MR4.0) | 6.5 y (5.0-9.7)/5.3 y (4.5-9.2) |
| Treatment time to 4.5 log reduction (MR4.5) | 10.7 y (7.7-13)/9.1 y (6.9-13) |
| Cumulative cure rate after 15 y of treatment | 14%/16% |
| Cumulative cure rate after 30 y of treatment | 31%/42% |
Time estimates represent medians and, in parentheses, interquartile ranges. Note that “cure” refers to complete eradication of MRD.