Summary of karyotypes of 28 paired AML samples procured at presentation and relapse: selected FISH results done for confirmation are presented
| AML no. . | Cytogenetics . | |
|---|---|---|
| Enrollment karyotype . | Relapse karyotype and selected FISH findings . | |
| MI-AML-002 | 46,XY,t(9;11)(p22;q23)[9]/45,idem,-Y[7]/46,XY[1] | 45,X,-Y,t(9;11)(p22;q23),del(11)(q22q25)[3]/45,X,-Y,t(2;6;18;4)(q11.2; q22;p11.2;q21),del(9)(q12q22),t(9;11),r(16)(p13;q?22)[3]/46,XX[13] |
| MI-AML-006 | 46,XY[20] | 46,XY[20] |
| MI-AML-015 | 46,XY[20] | 46,XY,del(6)(q13q25)[3]/46,XY[15]; FISH 5% + for del(6)(q13q25) |
| MI-AML-033 | 46,XY,del(3)(q13q27)[16]/46,XY[4] | 46,XY,del(3)(q13q27)[17]/46,XY[2] |
| MI-AML-036 | 46,XY,t(11;19)(q23;p13.1)[20] | 46,XY,t(11;19)(q23;p13.1)[19]/46,XY[1] |
| MI-AML-040 | 46,XY[20] | 46,XY[20] |
| MI-AML-044 | 46,XY,inv(9)(p11q13)c[23] | 45,X,-Y,inv(9)(p11q13)[3]/46,XY,inv(9)(p11q13)[17]; -Y not detected by FISH |
| MI-AML-057 | 46,XY,inv(16)(p13q22)[14] | 46,XY,del(7)(q22q36),inv(16)(p13.1q22)[1]/46,XY[19]; FISH 8.5% + for del(7)(q22q36) |
| MI-AML-068 | 46,XX,t(11;19)(q23;p13.1)[20] | 46,XX,t(11;19)(q23;p13.1)[18]/[46,XY[2] |
| MI-AML-069 | 46,XY,t(6;11)(q21;q23)[1]/47,sl,+der(6)t(6;11)(q21; q23)[1]/46,XY[16] | 46,XY,t(6;11)(q21;q23)[2]/46,XY[18] |
| MI-AML-078 | 46,XX,inv(16)(p13q22)[13]/46,XX[6] | 46,XX,inv(16)(p13q22)[20] |
| MI-AML-081 | 46,XX[20] | 46,XX[20] |
| MI-AML-090 | 46,XX[20] | 46,XX[20] |
| MI-AML-095 | 47,XX,+?4,del(?4)(q2?6q3?2)[2]/46,XX[15] | 47,XX,+?4,del(?4)(q2?6q3?2)[2]/46,XX[18] |
| MI-AML-098 | 46,XY[20] | 46,XY[20] |
| MI-AML-101 | 46,XY[20] | 46,XX[20] |
| MI-AML-103 | 47,XX,dic(8;21)(q21;q22),+dic(8;21)(p21; q22)x2[2]/46,XX[20] | 46,XX[20] |
| MI-AML-109 | 46,XX,t(8;21)(q22;q22)[19]/46,XX[1] | 46,XX,t(8;21)(q22;q22)[12]/46,XX[8] |
| MI-AML-126 | 47,XX,+8[4]/46,XX[16] | 47,XX,+8[3]/47,sl,del(16)(q12q22)[2]/46,XX[15] |
| MI-AML-129 | 47,XX,+8[17]/46,XX[3] | 47,XX,+8[6]/47,sl,del(20)(q11.2q13.3)[6]/47,sl,t(3;9)(q11.2;q22)[4]; FISH 28% + for del(20)(q11.2q13.3) |
| MI-AML-130 | 46,XY[20] | 46,XY[20] |
| MI-AML-131 | 46,XY[20] | 46,XY[20] |
| MI-AML-137 | 46,XY[20] | 46,XY[20] |
| MI-AML-159 | 46,XY,inv(16)(p13q22)[19]/46,XY[1] | 46,XY,inv(16)(p13q22)[19]/46,XY[1] |
| MI-AML-193 | 46,XX[20] | 46,XX[20] |
| MI-AML-233 | 46,XX[20] | 46,XX,t(3;12)(q27;q13)[15]/46,XX[5] |
| MI-AML-252 | 46,XY[20] | 46,XY[20] |
| MI-AML-274 | 45,X,-Y,del(12)(p12p13)[18]/46,XY[2] | 45,X,-Y,del(12)(p12p13)[6]/45,sl,t(6;13)(p12;q12)[7]/46,XY[7] |
| AML no. . | Cytogenetics . | |
|---|---|---|
| Enrollment karyotype . | Relapse karyotype and selected FISH findings . | |
| MI-AML-002 | 46,XY,t(9;11)(p22;q23)[9]/45,idem,-Y[7]/46,XY[1] | 45,X,-Y,t(9;11)(p22;q23),del(11)(q22q25)[3]/45,X,-Y,t(2;6;18;4)(q11.2; q22;p11.2;q21),del(9)(q12q22),t(9;11),r(16)(p13;q?22)[3]/46,XX[13] |
| MI-AML-006 | 46,XY[20] | 46,XY[20] |
| MI-AML-015 | 46,XY[20] | 46,XY,del(6)(q13q25)[3]/46,XY[15]; FISH 5% + for del(6)(q13q25) |
| MI-AML-033 | 46,XY,del(3)(q13q27)[16]/46,XY[4] | 46,XY,del(3)(q13q27)[17]/46,XY[2] |
| MI-AML-036 | 46,XY,t(11;19)(q23;p13.1)[20] | 46,XY,t(11;19)(q23;p13.1)[19]/46,XY[1] |
| MI-AML-040 | 46,XY[20] | 46,XY[20] |
| MI-AML-044 | 46,XY,inv(9)(p11q13)c[23] | 45,X,-Y,inv(9)(p11q13)[3]/46,XY,inv(9)(p11q13)[17]; -Y not detected by FISH |
| MI-AML-057 | 46,XY,inv(16)(p13q22)[14] | 46,XY,del(7)(q22q36),inv(16)(p13.1q22)[1]/46,XY[19]; FISH 8.5% + for del(7)(q22q36) |
| MI-AML-068 | 46,XX,t(11;19)(q23;p13.1)[20] | 46,XX,t(11;19)(q23;p13.1)[18]/[46,XY[2] |
| MI-AML-069 | 46,XY,t(6;11)(q21;q23)[1]/47,sl,+der(6)t(6;11)(q21; q23)[1]/46,XY[16] | 46,XY,t(6;11)(q21;q23)[2]/46,XY[18] |
| MI-AML-078 | 46,XX,inv(16)(p13q22)[13]/46,XX[6] | 46,XX,inv(16)(p13q22)[20] |
| MI-AML-081 | 46,XX[20] | 46,XX[20] |
| MI-AML-090 | 46,XX[20] | 46,XX[20] |
| MI-AML-095 | 47,XX,+?4,del(?4)(q2?6q3?2)[2]/46,XX[15] | 47,XX,+?4,del(?4)(q2?6q3?2)[2]/46,XX[18] |
| MI-AML-098 | 46,XY[20] | 46,XY[20] |
| MI-AML-101 | 46,XY[20] | 46,XX[20] |
| MI-AML-103 | 47,XX,dic(8;21)(q21;q22),+dic(8;21)(p21; q22)x2[2]/46,XX[20] | 46,XX[20] |
| MI-AML-109 | 46,XX,t(8;21)(q22;q22)[19]/46,XX[1] | 46,XX,t(8;21)(q22;q22)[12]/46,XX[8] |
| MI-AML-126 | 47,XX,+8[4]/46,XX[16] | 47,XX,+8[3]/47,sl,del(16)(q12q22)[2]/46,XX[15] |
| MI-AML-129 | 47,XX,+8[17]/46,XX[3] | 47,XX,+8[6]/47,sl,del(20)(q11.2q13.3)[6]/47,sl,t(3;9)(q11.2;q22)[4]; FISH 28% + for del(20)(q11.2q13.3) |
| MI-AML-130 | 46,XY[20] | 46,XY[20] |
| MI-AML-131 | 46,XY[20] | 46,XY[20] |
| MI-AML-137 | 46,XY[20] | 46,XY[20] |
| MI-AML-159 | 46,XY,inv(16)(p13q22)[19]/46,XY[1] | 46,XY,inv(16)(p13q22)[19]/46,XY[1] |
| MI-AML-193 | 46,XX[20] | 46,XX[20] |
| MI-AML-233 | 46,XX[20] | 46,XX,t(3;12)(q27;q13)[15]/46,XX[5] |
| MI-AML-252 | 46,XY[20] | 46,XY[20] |
| MI-AML-274 | 45,X,-Y,del(12)(p12p13)[18]/46,XY[2] | 45,X,-Y,del(12)(p12p13)[6]/45,sl,t(6;13)(p12;q12)[7]/46,XY[7] |