Table 3.

Characteristics and outcome for patients with MRD at day 28

CharacteristicDay 28 MRD−, n = 125Day 28 MRD+, n = 21P
N% or 95% CIN% or 95% CI
Sex      
 Male 51 40.8 17 81.0 <.001* 
 Female 74 59.2 4 19.0  
AML/MDS      
 AML 89 71.2 18 85.7 .164 
 MDS 36 28.8 3 14.3  
History of TMD      
 No 89 71.2 15 71.4 .983 
 Yes 36 28.8 6 28.6  
Trisomy 8      
 Absent 78 67.8 18 94.7 .016* 
 Present 37 32.2 1 5.3  
 Unknown 10  2   
Isolated trisomy      
 Absent 97 86.6 12 63.2 .050 
 Present 15 13.4 7 36.8  
 Unknown 10  2   
Induction I response by BM morphology      
 CR 110 91.7 13 68.4 .010* 
 PR 9 7.5 3 15.8 .213 
 RD 1 0.8 3 15.8 .008* 
 Unevaluable 5  2   
Outcome, from day 28 MRD      
 5-y DFS 92.7% 86.3-96.1 76.2% 51.9-89.3 .011* 
 5-y OS 96.8% 91.6-98.8 76.2% 51.9-89.3 <.001* 
CharacteristicDay 28 MRD−, n = 125Day 28 MRD+, n = 21P
N% or 95% CIN% or 95% CI
Sex      
 Male 51 40.8 17 81.0 <.001* 
 Female 74 59.2 4 19.0  
AML/MDS      
 AML 89 71.2 18 85.7 .164 
 MDS 36 28.8 3 14.3  
History of TMD      
 No 89 71.2 15 71.4 .983 
 Yes 36 28.8 6 28.6  
Trisomy 8      
 Absent 78 67.8 18 94.7 .016* 
 Present 37 32.2 1 5.3  
 Unknown 10  2   
Isolated trisomy      
 Absent 97 86.6 12 63.2 .050 
 Present 15 13.4 7 36.8  
 Unknown 10  2   
Induction I response by BM morphology      
 CR 110 91.7 13 68.4 .010* 
 PR 9 7.5 3 15.8 .213 
 RD 1 0.8 3 15.8 .008* 
 Unevaluable 5  2   
Outcome, from day 28 MRD      
 5-y DFS 92.7% 86.3-96.1 76.2% 51.9-89.3 .011* 
 5-y OS 96.8% 91.6-98.8 76.2% 51.9-89.3 <.001* 

BM, bone marrow.

*

Bold P values represent statistical significance <.05.

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