Table 2 Incidence of major thrombotic or... | American Society of Hematology

Table 2

Incidence of major thrombotic or bleeding events in patients with polycythemia vera or essential thrombocythemia according to age

Reference	MPN	Design	Patients (n)	Age range (y)	All thromboses (% per year)	Major bleeding (% per year)
GISP²	PV	Retrospective	82	<40	1.8	NA
			490	40-59	2.8	NA
			400	60-69	4.0	NA
			241	>70	5.1	NA
Passamonti et al³	PV	Retrospective	396	<65	1.5	NA
			396	>65	2.9	NA
Marchioli et al⁴	PV	Prospective	1638	<65*	2.5	0.8
				>65*	4.9
				<65†	5.0
				>65†	10.9
Cortelazzo et al³⁰	ET	Retrospective	34	<40‡	1.7	0.3
			37	40-60‡	6.3
			29	>60‡	15.1
Mc Intyre et al³⁸	ET	Retrospective	56	<40	2.2	1.1
Ruggeri et al³⁹	ET	Prospective	65	<60*	1.9	0
Alvarez-Larrán et al⁴⁰	ET	Retrospective	102	<60*^,‡	1.8	0.6
			198	<60*^,§	2.1	1.2
Barbui et al⁴¹	ET	Retrospective	213	<40	0.7	0.4

Reference	MPN	Design	Patients (n)	Age range (y)	All thromboses (% per year)	Major bleeding (% per year)
GISP²	PV	Retrospective	82	<40	1.8	NA
			490	40-59	2.8	NA
			400	60-69	4.0	NA
			241	>70	5.1	NA
Passamonti et al³	PV	Retrospective	396	<65	1.5	NA
			396	>65	2.9	NA
Marchioli et al⁴	PV	Prospective	1638	<65*	2.5	0.8
				>65*	4.9
				<65†	5.0
				>65†	10.9
Cortelazzo et al³⁰	ET	Retrospective	34	<40‡	1.7	0.3
			37	40-60‡	6.3
			29	>60‡	15.1
Mc Intyre et al³⁸	ET	Retrospective	56	<40	2.2	1.1
Ruggeri et al³⁹	ET	Prospective	65	<60*	1.9	0
Alvarez-Larrán et al⁴⁰	ET	Retrospective	102	<60*^,‡	1.8	0.6
			198	<60*^,§	2.1	1.2
Barbui et al⁴¹	ET	Retrospective	213	<40	0.7	0.4

NA, not available.

Without previous thrombosis.

With previous thrombosis.

Without antiplatelet therapy.

With antiplatelet therapy.