Identification of microRNA that significantly affected the expression of the corresponding target genes in a combined analysis of ITP patients and controls
| microRNA . | TargetScan . | Miranda . |
|---|---|---|
| miR-877 | 1.5 × 10−27 | 5.3 × 10−27 |
| miR-671-5p | 2.3 × 10−21 | 2.2 × 10−11 |
| miR-494 | 7.3 × 10−131 | 2.9 × 10−133 |
| miR-4270 | NA | 5.7 × 10−11 |
| miR-363 | 9.7 × 10−29 | 9.5 × 10−54 |
| miR-3162 | NA | 3.2 × 10−14 |
| miR-30a | 1.9 × 10−73 | 5.8 × 10−138 |
| miR-197 | 2.8 × 10−63 | 2.5 × 10−33 |
| miR-150-star | NA | 2.6 × 10−53 |
| miR-149-star | NA | 1.4 × 10−04 |
| miR-1280 | 4.3 × 10−18 | 2.5 × 10−05 |
| miR-1275 | 1.5 × 10−11 | 1.2 × 10−03 |
| miR-1268 | 7.6 × 10−06 | 5.6 × 10−01 |
| miR-1260b | NA | 2.9 × 10−09 |
| miR-125a-5p | 7.4 × 10−12 | 7.8 × 10−10 |
| miR-1207-5p | 7.5 × 10−07 | 3.2 × 10−01 |
| let-7b | 5.6 × 10−21 | 2.0 × 10−18 |
| microRNA . | TargetScan . | Miranda . |
|---|---|---|
| miR-877 | 1.5 × 10−27 | 5.3 × 10−27 |
| miR-671-5p | 2.3 × 10−21 | 2.2 × 10−11 |
| miR-494 | 7.3 × 10−131 | 2.9 × 10−133 |
| miR-4270 | NA | 5.7 × 10−11 |
| miR-363 | 9.7 × 10−29 | 9.5 × 10−54 |
| miR-3162 | NA | 3.2 × 10−14 |
| miR-30a | 1.9 × 10−73 | 5.8 × 10−138 |
| miR-197 | 2.8 × 10−63 | 2.5 × 10−33 |
| miR-150-star | NA | 2.6 × 10−53 |
| miR-149-star | NA | 1.4 × 10−04 |
| miR-1280 | 4.3 × 10−18 | 2.5 × 10−05 |
| miR-1275 | 1.5 × 10−11 | 1.2 × 10−03 |
| miR-1268 | 7.6 × 10−06 | 5.6 × 10−01 |
| miR-1260b | NA | 2.9 × 10−09 |
| miR-125a-5p | 7.4 × 10−12 | 7.8 × 10−10 |
| miR-1207-5p | 7.5 × 10−07 | 3.2 × 10−01 |
| let-7b | 5.6 × 10−21 | 2.0 × 10−18 |
There were 22 microRNA that significantly differed between ITP patients and controls. To evaluate if these were associated with changes in the mRNA expression of the target genes the TargetScan and Miranda algorithms were used and Kolmogorov-Smirnov statistics applied. This resulted in 17 microRNA that were significantly associated with mRNA expression in the database.
NA, not available.