Problems and their solutions during the development of the IC-APL network
| Problem . | Solution . |
|---|---|
| Delay in initiating ATRA and supportive measures to counteract APL-associated coagulopathy | Rapid diagnosis using the anti-PML immunofluorescence technique Establishment of small stocks of ATRA in emergency rooms and intensive care units Educational measures focusing on hematologists and nonhematologists (guidelines) |
| Difficulties in confirming APL diagnosis and identification of variants | Availability of (cyto)genetic tests through network |
| High morbidity/mortality of DS syndrome | Educational measures focusing on early detection and treatment |
| Unavailability of MRD investigation | Standardization of RT-PCR techniques for MRD detection at national laboratories with the input of international reference laboratories |
| Minimal experience in conducting clinical trials and quality control of data and samples | Training of young investigators Web-based case, protocol, and guideline discussions Data management via web using POND Development and maintenance of a biobank Centralized statistical analysis |
| Problem . | Solution . |
|---|---|
| Delay in initiating ATRA and supportive measures to counteract APL-associated coagulopathy | Rapid diagnosis using the anti-PML immunofluorescence technique Establishment of small stocks of ATRA in emergency rooms and intensive care units Educational measures focusing on hematologists and nonhematologists (guidelines) |
| Difficulties in confirming APL diagnosis and identification of variants | Availability of (cyto)genetic tests through network |
| High morbidity/mortality of DS syndrome | Educational measures focusing on early detection and treatment |
| Unavailability of MRD investigation | Standardization of RT-PCR techniques for MRD detection at national laboratories with the input of international reference laboratories |
| Minimal experience in conducting clinical trials and quality control of data and samples | Training of young investigators Web-based case, protocol, and guideline discussions Data management via web using POND Development and maintenance of a biobank Centralized statistical analysis |