Changes in host coagulation parameters following infection with 2.5 × 108 CFUs S. aureus
| Parameter . | Unchallenged . | 24 h post-infection . | 48 h post-infection . | |||
|---|---|---|---|---|---|---|
| Wild-type N = 3 . | FibγΔ5 N = 3 . | Wild-type N = 4 . | FibγΔ5 N = 4 . | Wild-type N = 4 . | FibγΔ5 N = 4 . | |
| TAT (μg/L) | 26 ± 2.1 | 27 ± 3.2 | 54 ± 6.1 | 60 ± 2.4 | 25 ± 3.7 | 40 ± 1.3* |
| Fibrinogen (mg/mL) | 2.8 ± 0.1 | 2.3 ± 0.3 | 4.1 ± 0.7 | 4.3 ± 0.1 | 4.8 ± 0.3 | 5.2 ± 0.1 |
| Parameter . | Unchallenged . | 24 h post-infection . | 48 h post-infection . | |||
|---|---|---|---|---|---|---|
| Wild-type N = 3 . | FibγΔ5 N = 3 . | Wild-type N = 4 . | FibγΔ5 N = 4 . | Wild-type N = 4 . | FibγΔ5 N = 4 . | |
| TAT (μg/L) | 26 ± 2.1 | 27 ± 3.2 | 54 ± 6.1 | 60 ± 2.4 | 25 ± 3.7 | 40 ± 1.3* |
| Fibrinogen (mg/mL) | 2.8 ± 0.1 | 2.3 ± 0.3 | 4.1 ± 0.7 | 4.3 ± 0.1 | 4.8 ± 0.3 | 5.2 ± 0.1 |
P < 0.05 by Student t test relative to value in wild-type mice 48 h after infection.