Table 1

Characterization of various nanoparticle formulations

FormulationParticle size, nm*Zeta potential, mV
Naked nanoparticles 49.3 ± 5.2 4.22 ± 0.82 
HER-INPs 55.6 ± 7.4 4.25 ± 0.65 
RIT-INPs 56.3 ± 7.5 2.09 ± 0.31 
FormulationParticle size, nm*Zeta potential, mV
Naked nanoparticles 49.3 ± 5.2 4.22 ± 0.82 
HER-INPs 55.6 ± 7.4 4.25 ± 0.65 
RIT-INPs 56.3 ± 7.5 2.09 ± 0.31 

Molar ratio of ILPs was 3β-N-(N′,N′-dimethyl amino ethane)-carbamoyl cholesterol/egg phosphatidylcholine/methoxy polyethylene glycol–distearoyl phosphatidylethanolamine = 28/70/2; weight ratio was lipids/ODN/protamine = 12.5/1/0.3; 0.05 mol % Herceptin or rituximab was conjugated on INPs. The encapsulation efficiency of ODNs was above 90%.

*

The representative data are from the mean of 3 separate measurements.

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