Table 1 FVIII:C and VWF binding of O... | American Society of Hematology

Table 1

FVIII:C and VWF binding of O-glycoPEGylated FVIII conjugates

FVIII conjugate	Specific activity (U/mg)	K_d for VWF binding (nM)
FVIII	9600 ± 740	0.22 ± 0.02
10-kDa PEG-FVIII	11 040 ± 1050	0.20 ± 0.01
20-kDa PEG-FVIII	11 460 ± 540	0.23 ± 0.02
40-kDa PEG-FVIII	11 200 ± 1050	0.30 ± 0.03
80-kDa PEG-FVIII	11 340 ± 150	0.38 ± 0.04

FVIII conjugate	Specific activity (U/mg)	K_d for VWF binding (nM)
FVIII	9600 ± 740	0.22 ± 0.02
10-kDa PEG-FVIII	11 040 ± 1050	0.20 ± 0.01
20-kDa PEG-FVIII	11 460 ± 540	0.23 ± 0.02
40-kDa PEG-FVIII	11 200 ± 1050	0.30 ± 0.03
80-kDa PEG-FVIII	11 340 ± 150	0.38 ± 0.04

Data are mean and standard deviation of 3 independent assays.