Table 1 CLL genotype data for R620W... | American Society of Hematology

Table 1

CLL genotype data for R620W variant or surrogate rs6679677

Marshfield PMRP*
Rs2476601	CLL⁺	CLL⁻‡
GG	25	3432
AG	12	720
AA	0	47

GEC Consortium†
Rs6679677	CLL⁺	CLL⁻‡
CC	310	247
AC	91	44
AA	6	5

Fisher exact test (carriers vs noncarriers) P = .033; Cochran-Armitage Trend Test P = .062. AA + AG vs GG genotype odds ratio = 2.15; 95% confidence interval, 1.07-4.29.

†

Fisher exact test (carriers vs noncarriers) P = .019; Cochran-Armitage Trend Test P = .041. AA + AC vs CC genotype odds ratio = 1.58; 95% confidence interval, 1.08-2.31.

‡

The increased 620W frequency in GEC/PMRP controls over those in Negro et al reflects the well-described strong gradient from southern to northern/northeastern Europe.¹

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