Clinical and laboratory features of microangiopathies of pregnancy
| Feature . | Preeclampsia . | HELLP . | AFLP . | aHUS . | TTP . | CAPS . | SLE . |
|---|---|---|---|---|---|---|---|
| Hypertension | +++ | +++ | + | ++ | + | +/− | ++ |
| Proteinuria | +++ | ++ | +/− | +++ | +/− | + | +++ |
| Nausea/vomiting | + | + | ++ | +/− | +/− | +/− | +/− |
| Abdominal pain | +/− | ++ | ++ | +/− | +/− | +/− | +/− |
| Jaundice | +/− | +/− | ++ | +/− | +/− | +/− | +/− |
| Neurologic symptoms | + | + | + | +/− | ++ | ++ | + |
| Thrombocytopenia | + | +++ | + | +++ | +++ | + | + |
| Hemolysis | +/− | +++ | + | +++ | +++ | +/− | + |
| Raised bilirubin | +/− | +++ | +++ | +++ | +++ | +/− | +/− |
| Renal impairment | +/− | + | ++ | +++ | + | ++ | ++ |
| DIC | +/− | ++ | +++ | +/− | +/− | +/− | +/− |
| Hypoglycemia | +/− | +/− | +++ | +/− | +/− | +/− | +/− |
| Elevated ammonia | +/− | +/− | + | +/− | +/− | +/− | +/− |
| Elevated transaminases | + | +++ | +++ | +/− | +/− | +/− | + |
| Peak time of onset | Third trimester | Third trimester | Third trimester | Postpartum | Second or third trimester | Anytime | Anytime |
| Feature . | Preeclampsia . | HELLP . | AFLP . | aHUS . | TTP . | CAPS . | SLE . |
|---|---|---|---|---|---|---|---|
| Hypertension | +++ | +++ | + | ++ | + | +/− | ++ |
| Proteinuria | +++ | ++ | +/− | +++ | +/− | + | +++ |
| Nausea/vomiting | + | + | ++ | +/− | +/− | +/− | +/− |
| Abdominal pain | +/− | ++ | ++ | +/− | +/− | +/− | +/− |
| Jaundice | +/− | +/− | ++ | +/− | +/− | +/− | +/− |
| Neurologic symptoms | + | + | + | +/− | ++ | ++ | + |
| Thrombocytopenia | + | +++ | + | +++ | +++ | + | + |
| Hemolysis | +/− | +++ | + | +++ | +++ | +/− | + |
| Raised bilirubin | +/− | +++ | +++ | +++ | +++ | +/− | +/− |
| Renal impairment | +/− | + | ++ | +++ | + | ++ | ++ |
| DIC | +/− | ++ | +++ | +/− | +/− | +/− | +/− |
| Hypoglycemia | +/− | +/− | +++ | +/− | +/− | +/− | +/− |
| Elevated ammonia | +/− | +/− | + | +/− | +/− | +/− | +/− |
| Elevated transaminases | + | +++ | +++ | +/− | +/− | +/− | + |
| Peak time of onset | Third trimester | Third trimester | Third trimester | Postpartum | Second or third trimester | Anytime | Anytime |
CAPS indicates catastrophic antiphospholipid syndrome; +/−, rare or absent (0%-20% of cases); +, fairly common (20%-50% of cases); ++, common (50%-80% of cases); and +++, very common or constant feature (80%-100% of cases).