Therapeutic options for ITP in pregnancy
| First-line therapy . | Intravenous gammaglobulin (IVIg) oral corticosteroids . |
|---|---|
| Second line* | Combination therapy with corticosteroids and IVIg |
| Splenectomy (second trimester) | |
| Other therapeutic options† | |
| Relatively contraindicated | Anti-D immunoglobulin [C] |
| Azathioprine [D] | |
| Not recommended but use in pregnancy described | Cyclosporine A [C] |
| Dapsone [C] | |
| Thrombopoietin receptor agonists [C]‡ | |
| Campath-1H [C] | |
| Rituximab [C] | |
| Contraindicated | Mycophenolate mofetil [C] |
| Cyclophosphamide [D] | |
| Vinca alkaloids [D] | |
| Danazol [X] |
| First-line therapy . | Intravenous gammaglobulin (IVIg) oral corticosteroids . |
|---|---|
| Second line* | Combination therapy with corticosteroids and IVIg |
| Splenectomy (second trimester) | |
| Other therapeutic options† | |
| Relatively contraindicated | Anti-D immunoglobulin [C] |
| Azathioprine [D] | |
| Not recommended but use in pregnancy described | Cyclosporine A [C] |
| Dapsone [C] | |
| Thrombopoietin receptor agonists [C]‡ | |
| Campath-1H [C] | |
| Rituximab [C] | |
| Contraindicated | Mycophenolate mofetil [C] |
| Cyclophosphamide [D] | |
| Vinca alkaloids [D] | |
| Danazol [X] |
For refractory thrombocytopenia or poorly tolerated side effects.
FDA designated pregnancy category in brackets.
As reported on the official package inserts (http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm), although no studies have been published.