Table 4 Therapeutic options for ITP in... | American Society of Hematology

Table 4

Therapeutic options for ITP in pregnancy

First-line therapy	Intravenous gammaglobulin (IVIg) oral corticosteroids
Second line*	Combination therapy with corticosteroids and IVIg
	Splenectomy (second trimester)
Other therapeutic options†
Relatively contraindicated	Anti-D immunoglobulin [C]
	Azathioprine [D]
Not recommended but use in pregnancy described	Cyclosporine A [C]
	Dapsone [C]
	Thrombopoietin receptor agonists [C]‡
	Campath-1H [C]
	Rituximab [C]
Contraindicated	Mycophenolate mofetil [C]
	Cyclophosphamide [D]
	Vinca alkaloids [D]
	Danazol [X]

First-line therapy	Intravenous gammaglobulin (IVIg) oral corticosteroids
Second line*	Combination therapy with corticosteroids and IVIg
	Splenectomy (second trimester)
Other therapeutic options†
Relatively contraindicated	Anti-D immunoglobulin [C]
	Azathioprine [D]
Not recommended but use in pregnancy described	Cyclosporine A [C]
	Dapsone [C]
	Thrombopoietin receptor agonists [C]‡
	Campath-1H [C]
	Rituximab [C]
Contraindicated	Mycophenolate mofetil [C]
	Cyclophosphamide [D]
	Vinca alkaloids [D]
	Danazol [X]

For refractory thrombocytopenia or poorly tolerated side effects.

FDA designated pregnancy category in brackets.

As reported on the official package inserts (http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm), although no studies have been published.