Table 2 Outcome after 5 years according... | American Society of Hematology

Table 2

Outcome after 5 years according to molecular response after induction (day 71) and consolidation (week 16)

Parameter	Day 71 after induction					P	Week 16 after consolidation					P
	N	MolCR		MolFail			N	MolCR		MolFail
	N	n	% ± SD	n	% ± SD		N	n	% ± SD	n	% ± SD
Standard risk
CCR	434	335	69 ± 3	99	42 ± 6	< .0001	424	335	74 ± 3	89	37 ± 6	< .0001
CCR SCT excluded	384	317	69 ± 3	67	32 ± 7	<.0001	376	322	74 ± 3	54	13 ± 5	< .0001
DFS	434	335	62 ± 3	99	35 ± 6	< .0001	424	335	68 ± 3	89	28 ± 5	< .0001
DFS SCT excluded	384	317	62 ± 3	67	27 ± 6*	< .0001	376	322	68 ± 3	54	11 ± 5	< .0001
Overall survival	434	335	80 ± 3	99	47 ± 6	< .0001	424	335	81 ± 3	89	43 ± 6	< .0001
Overall survival SCT excluded	384	317	80 ± 3	67	38 ± 7	< .0001	376	322	81 ± 3	54	31 ± 7	< .0001
High risk
CCR	145	72	78 ± 8	73	41 ± 7	< .0001	80	49	75 ± 8	31	29 ± 12	< .0001
CCR SCT excluded	40	16	36 ± 26	24	21 ± 10	.001	20	11	50 ± 35	9	19 ± 17	< .0001
DFS	145	72	66 ± 8	73	32 ± 6	< .0001	80	49	64 ± 8*	31	18 ± 8*	< .0001
DFS SCT excluded	40	16	18 ± 15*	24	6 ± 5*	.003	20	11	34 ± 26*	9	11 ± 10*	.0009
Overall survival	146	72	72 ± 8	74	49 ± 7	.0005	80	49	71 ± 9	31	41 ± 10	.003
Overall survival SCT excluded	40	16	56 ± 17	24	21 ± 9	.06	20	11	83 ± 15	9	44 ± 17	NS
Overall
CCR	579*	407	70 ± 3	172	39 ± 5	< .0001	504	384	74 ± 3	120	35 ± 5	< .0001
CCR SCT excluded	424	333	68 ± 3	91	26 ± 6	< .0001	396	333	74 ± 3	63	12 ± 5	< .000
DFS	579	407	63 ± 3	172	31 ± 4	< .0001	504	384	67 ± 3	120	25 ± 5	< .0001
DFS SCT excluded	424	333	60 ± 3	91	20 ± 5	< .0001	396	333	68 ± 3	63	10 ± 4	< .0001
Overall survival	580	407	79 ± 3	173	47 ± 5	< .0001	504	384	80 ± 3	120	42 ± 5	< .0001
Overall survival SCT excluded	424	333	80 ± 3	91	36 ± 6	< .0001	396	333	81 ± 3	63	33 ± 7	< .0001

Parameter	Day 71 after induction					P	Week 16 after consolidation					P
	N	MolCR		MolFail			N	MolCR		MolFail
	N	n	% ± SD	n	% ± SD		N	n	% ± SD	n	% ± SD
Standard risk
CCR	434	335	69 ± 3	99	42 ± 6	< .0001	424	335	74 ± 3	89	37 ± 6	< .0001
CCR SCT excluded	384	317	69 ± 3	67	32 ± 7	<.0001	376	322	74 ± 3	54	13 ± 5	< .0001
DFS	434	335	62 ± 3	99	35 ± 6	< .0001	424	335	68 ± 3	89	28 ± 5	< .0001
DFS SCT excluded	384	317	62 ± 3	67	27 ± 6*	< .0001	376	322	68 ± 3	54	11 ± 5	< .0001
Overall survival	434	335	80 ± 3	99	47 ± 6	< .0001	424	335	81 ± 3	89	43 ± 6	< .0001
Overall survival SCT excluded	384	317	80 ± 3	67	38 ± 7	< .0001	376	322	81 ± 3	54	31 ± 7	< .0001
High risk
CCR	145	72	78 ± 8	73	41 ± 7	< .0001	80	49	75 ± 8	31	29 ± 12	< .0001
CCR SCT excluded	40	16	36 ± 26	24	21 ± 10	.001	20	11	50 ± 35	9	19 ± 17	< .0001
DFS	145	72	66 ± 8	73	32 ± 6	< .0001	80	49	64 ± 8*	31	18 ± 8*	< .0001
DFS SCT excluded	40	16	18 ± 15*	24	6 ± 5*	.003	20	11	34 ± 26*	9	11 ± 10*	.0009
Overall survival	146	72	72 ± 8	74	49 ± 7	.0005	80	49	71 ± 9	31	41 ± 10	.003
Overall survival SCT excluded	40	16	56 ± 17	24	21 ± 9	.06	20	11	83 ± 15	9	44 ± 17	NS
Overall
CCR	579*	407	70 ± 3	172	39 ± 5	< .0001	504	384	74 ± 3	120	35 ± 5	< .0001
CCR SCT excluded	424	333	68 ± 3	91	26 ± 6	< .0001	396	333	74 ± 3	63	12 ± 5	< .000
DFS	579	407	63 ± 3	172	31 ± 4	< .0001	504	384	67 ± 3	120	25 ± 5	< .0001
DFS SCT excluded	424	333	60 ± 3	91	20 ± 5	< .0001	396	333	68 ± 3	63	10 ± 4	< .0001
Overall survival	580	407	79 ± 3	173	47 ± 5	< .0001	504	384	80 ± 3	120	42 ± 5	< .0001
Overall survival SCT excluded	424	333	80 ± 3	91	36 ± 6	< .0001	396	333	81 ± 3	63	33 ± 7	< .0001

MolCR indicates molecular complete response; molFail, molecular failure; CCR, continuous complete remission; SCT, stem cell transplantation; and DFS, disease-free survival.

Five years not reached.

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