Cytologic and molecular response rates after induction therapy (day 71) in correlation to prognostic factors
| . | Cytologic CR rate . | Molecular CR rate . | ||||
|---|---|---|---|---|---|---|
| N (%)* . | n (%) . | P† . | N (%)* . | n (%) . | P† . | |
| Total | 1648 | 1467 (89) | 580 | 407 (70) | ||
| Risk groups | .0001 | < .0001 | ||||
| Standard risk | 975 (59) | 895 (92) | 434 (75) | 335 (77) | ||
| High risk | 673 (41) | 572 (85) | 146 (25) | 72 (51) | ||
| Immunophenotype | ||||||
| B lineage | 1076 (65) | 961 (89) | NS | 383 (66) | 252 (66) | .001 |
| T lineage | 569 (35) | 504 (89) | NS | 197 (34) | 155 (79) | .001 |
| c-ALL | 912 (56) | 813 (89) | .0009 | 350 (61) | 236 (67) | < .0001 |
| Pro-B-ALL | 169 (10) | 148 (90) | .0009 | 33 (6) | 16 (48) | < .0001 |
| Early T-ALL | 151 (9) | 129 (85) | .0009 | 21 (4) | 10 (45) | < .0001 |
| Mature T-ALL | 97 (6) | 76 (78) | .0009 | 23 (4) | 9 (39) | < .0001 |
| Thymic T-ALL | 303 (19) | 282 (93) | .0009 | 151 (26) | 134 (89) | < .0001 |
| Age | .01 | NS | ||||
| 15-35 y | 982 (60) | 890 (91) | 375 (65) | 266 (71) | ||
| 35-55 y | 666 (40) | 577 (87) | 205 (35) | 141 (69) | ||
| Leukocyte count | ||||||
| B lineage | NS | .06 | ||||
| < 30 000/μL | 783 (73) | 706 (90) | 316 (83) | 215 (68) | ||
| > 30 000/μL | 288 (27) | 251 (87) | 66 (17) | 37 (56) | ||
| T-lineage | NS | NS | ||||
| < 100 000/μL | 416 (76) | 372 (89) | 145 (74) | 118 (81) | ||
| > 100 000/μL | 134 (24) | 116 (87) | 51 (26) | 36 (71) | ||
| . | Cytologic CR rate . | Molecular CR rate . | ||||
|---|---|---|---|---|---|---|
| N (%)* . | n (%) . | P† . | N (%)* . | n (%) . | P† . | |
| Total | 1648 | 1467 (89) | 580 | 407 (70) | ||
| Risk groups | .0001 | < .0001 | ||||
| Standard risk | 975 (59) | 895 (92) | 434 (75) | 335 (77) | ||
| High risk | 673 (41) | 572 (85) | 146 (25) | 72 (51) | ||
| Immunophenotype | ||||||
| B lineage | 1076 (65) | 961 (89) | NS | 383 (66) | 252 (66) | .001 |
| T lineage | 569 (35) | 504 (89) | NS | 197 (34) | 155 (79) | .001 |
| c-ALL | 912 (56) | 813 (89) | .0009 | 350 (61) | 236 (67) | < .0001 |
| Pro-B-ALL | 169 (10) | 148 (90) | .0009 | 33 (6) | 16 (48) | < .0001 |
| Early T-ALL | 151 (9) | 129 (85) | .0009 | 21 (4) | 10 (45) | < .0001 |
| Mature T-ALL | 97 (6) | 76 (78) | .0009 | 23 (4) | 9 (39) | < .0001 |
| Thymic T-ALL | 303 (19) | 282 (93) | .0009 | 151 (26) | 134 (89) | < .0001 |
| Age | .01 | NS | ||||
| 15-35 y | 982 (60) | 890 (91) | 375 (65) | 266 (71) | ||
| 35-55 y | 666 (40) | 577 (87) | 205 (35) | 141 (69) | ||
| Leukocyte count | ||||||
| B lineage | NS | .06 | ||||
| < 30 000/μL | 783 (73) | 706 (90) | 316 (83) | 215 (68) | ||
| > 30 000/μL | 288 (27) | 251 (87) | 66 (17) | 37 (56) | ||
| T-lineage | NS | NS | ||||
| < 100 000/μL | 416 (76) | 372 (89) | 145 (74) | 118 (81) | ||
| > 100 000/μL | 134 (24) | 116 (87) | 51 (26) | 36 (71) | ||