Serious adverse events and infections
| Parameter . | RTX+DXM . | DXM . |
|---|---|---|
| Total serious adverse events | 16 | 9 |
| Thrombocytopenia (without bleeding) requiring hospitalization | 5 | 0 |
| Bleeding grade 3-4 | 2 | 1 |
| Deaths | 1* | 3† |
| Fever | 2 | 1 |
| Pain | 1 | 1 |
| Dizziness | 1 | 1 |
| Infusion-related anaphylaxis | 1 | 0 |
| Delayed neutropenia | 1 | 0 |
| Vasculitis | 1 | 0 |
| Cataract | 1 | 0 |
| Hyperglycemia | 0 | 1 |
| Chest pain | 0 | 1 |
| Total reported infections | 11 | 9 |
| Upper respiratory tract | 4 | 1 |
| Topical | 4‡ | 1§ |
| Oral candida | 0 | 3 |
| Pneumonia | 2 | 2 |
| Urinary tract | 1 | 2 |
| Herpes genitalis | 1 | 1 |
| Parameter . | RTX+DXM . | DXM . |
|---|---|---|
| Total serious adverse events | 16 | 9 |
| Thrombocytopenia (without bleeding) requiring hospitalization | 5 | 0 |
| Bleeding grade 3-4 | 2 | 1 |
| Deaths | 1* | 3† |
| Fever | 2 | 1 |
| Pain | 1 | 1 |
| Dizziness | 1 | 1 |
| Infusion-related anaphylaxis | 1 | 0 |
| Delayed neutropenia | 1 | 0 |
| Vasculitis | 1 | 0 |
| Cataract | 1 | 0 |
| Hyperglycemia | 0 | 1 |
| Chest pain | 0 | 1 |
| Total reported infections | 11 | 9 |
| Upper respiratory tract | 4 | 1 |
| Topical | 4‡ | 1§ |
| Oral candida | 0 | 3 |
| Pneumonia | 2 | 2 |
| Urinary tract | 1 | 2 |
| Herpes genitalis | 1 | 1 |
84-y-old female deceased from pneumonia and heart failure 33 mo after inclusion.
83-y-old female deceased from atrial fibrillation and sepsis 3 wk after inclusion; 80-y-old male deceased in own home 4 d after inclusion, cause unknown; 80-y-old woman deceased 33 mo after inclusion, cause unknown.
Bursitis, otitis, bartholinitis, and eye infection.
Furunculi.
In both groups, age at the time of inclusion was in the range of 18 to 84 years.