Differential expression and overlap with Ikaros-regulated genes
| . | Differential expression MLP to CLP . | Differential expression CLP to DP thymocytes . | ||||
|---|---|---|---|---|---|---|
| . | All . | Up-regulated . | Down-regulated . | All . | Up-regulated . | Down-regulated . |
| All genes (16 291) | 868 | 362 | 506 | 7753 | 3849 | 3904 |
| Overlap with Ikaros-regulated genes | ||||||
| 2-h Gene set (79) | 18 | 13 | 5 | 54 | 11 | 43 |
| P value | 2.23 x10−8 | 1.88 × 10−9 | 0.036 | 5.9 × 10−5 | 0.98 | 1.33 × 10−9 |
| Odds ratio | 4.346 | 7.644 | 2.048 | 1.44 | 0.59 | 2.29 |
| 6-h Gene set (401) | 64 | 34 | 30 | 256 | 56 | 200 |
| P value | 5.88 × 10−16 | 4.82 × 10−12 | 3.13 × 10−6 | 1.26 × 10−11 | 1.00 | 1.39 × 10−30 |
| Odds ratio | 3.154 | 4.108 | 2.497 | 1.35 | 0.59 | 2.14 |
| 48-h Gene set (4471) | 322 | 147 | 175 | 2464 | 567 | 1897 |
| P value | 7.55 × 1011 | 1.66 × 10−8 | 1.40 × 10−4 | 1.26 × 10−32 | 1 | 8.13 × 10−237 |
| Odds ratio | 1.559 | 1.808 | 1.398 | 1.23 | 0.46 | 2.50 |
| Overlap with Ikaros-bound genes | ||||||
| Bound gene set (5732) | 390 | 192 | 198 | 2842 | 899 | 1943 |
| P value | 4.71 × 10−10 | 7.70 × 10−13 | 0.027 | 8.36 × 10−5 | 1 | 1.21 × 10−103 |
| Odds ratio | 1.50 | 2.08 | 1.18 | 1.07 | 0.56 | 1.83 |
| All genes (16 291) | 2323 | 1095 | 1228 | 2496 | 831 | 1665 |
| Overlap with Ikaros-regulated genes | ||||||
| 2-h Gene set (79) | 21 | 16 | 5 | 23 | 12 | 11 |
| P value | 0.001 | 1.55 × 10−5 | 0.55 | 5.33 × 10−4 | 1.67 × 10−4 | 0.11 |
| Odds ratio | 1.872 | 3.043 | 0.839 | 1.91 | 3.01 | 1.36 |
| 6-h Gene set (401) | 117 | 84 | 33 | 169 | 46 | 123 |
| P value | 1.74 × 10−15 | 6.69 × 10−22 | 0.26 | 9.60 × 10−40 | 8.78 × 10−8 | 4.35 × 10−31 |
| Odds ratio | 2.101 | 3.292 | 1.094 | 2.879 | 2.322 | 3.161 |
| 48-h Gene set (4471) | 926 | 588 | 338 | 1523 | 397 | 1126 |
| P value | 2.93 × 10−45 | 3.22 × 10−81 | 0.46 | 0.00 | 4.26 × 10−38 | 6.75 × 10−290 |
| Odds ratio | 1.752 | 3.066 | 1.00 | 4.13 | 2.42 | 5.52 |
| Overlap with Ikaros-bound genes | ||||||
| Bound gene set (5732) | 1125 | 662 | 463 | 1283 | 472 | 811 |
| P value | 4.13 × 1046 | 3.59 × 10−70 | 0.026 | 1.52 × 10−73 | 2.24 × 10−39 | 1.96 × 10−33 |
| Odds ratio | 1.73 | 2.82 | 1.11 | 1.95 | 2.42 | 1.75 |
| . | Differential expression MLP to CLP . | Differential expression CLP to DP thymocytes . | ||||
|---|---|---|---|---|---|---|
| . | All . | Up-regulated . | Down-regulated . | All . | Up-regulated . | Down-regulated . |
| All genes (16 291) | 868 | 362 | 506 | 7753 | 3849 | 3904 |
| Overlap with Ikaros-regulated genes | ||||||
| 2-h Gene set (79) | 18 | 13 | 5 | 54 | 11 | 43 |
| P value | 2.23 x10−8 | 1.88 × 10−9 | 0.036 | 5.9 × 10−5 | 0.98 | 1.33 × 10−9 |
| Odds ratio | 4.346 | 7.644 | 2.048 | 1.44 | 0.59 | 2.29 |
| 6-h Gene set (401) | 64 | 34 | 30 | 256 | 56 | 200 |
| P value | 5.88 × 10−16 | 4.82 × 10−12 | 3.13 × 10−6 | 1.26 × 10−11 | 1.00 | 1.39 × 10−30 |
| Odds ratio | 3.154 | 4.108 | 2.497 | 1.35 | 0.59 | 2.14 |
| 48-h Gene set (4471) | 322 | 147 | 175 | 2464 | 567 | 1897 |
| P value | 7.55 × 1011 | 1.66 × 10−8 | 1.40 × 10−4 | 1.26 × 10−32 | 1 | 8.13 × 10−237 |
| Odds ratio | 1.559 | 1.808 | 1.398 | 1.23 | 0.46 | 2.50 |
| Overlap with Ikaros-bound genes | ||||||
| Bound gene set (5732) | 390 | 192 | 198 | 2842 | 899 | 1943 |
| P value | 4.71 × 10−10 | 7.70 × 10−13 | 0.027 | 8.36 × 10−5 | 1 | 1.21 × 10−103 |
| Odds ratio | 1.50 | 2.08 | 1.18 | 1.07 | 0.56 | 1.83 |
| All genes (16 291) | 2323 | 1095 | 1228 | 2496 | 831 | 1665 |
| Overlap with Ikaros-regulated genes | ||||||
| 2-h Gene set (79) | 21 | 16 | 5 | 23 | 12 | 11 |
| P value | 0.001 | 1.55 × 10−5 | 0.55 | 5.33 × 10−4 | 1.67 × 10−4 | 0.11 |
| Odds ratio | 1.872 | 3.043 | 0.839 | 1.91 | 3.01 | 1.36 |
| 6-h Gene set (401) | 117 | 84 | 33 | 169 | 46 | 123 |
| P value | 1.74 × 10−15 | 6.69 × 10−22 | 0.26 | 9.60 × 10−40 | 8.78 × 10−8 | 4.35 × 10−31 |
| Odds ratio | 2.101 | 3.292 | 1.094 | 2.879 | 2.322 | 3.161 |
| 48-h Gene set (4471) | 926 | 588 | 338 | 1523 | 397 | 1126 |
| P value | 2.93 × 10−45 | 3.22 × 10−81 | 0.46 | 0.00 | 4.26 × 10−38 | 6.75 × 10−290 |
| Odds ratio | 1.752 | 3.066 | 1.00 | 4.13 | 2.42 | 5.52 |
| Overlap with Ikaros-bound genes | ||||||
| Bound gene set (5732) | 1125 | 662 | 463 | 1283 | 472 | 811 |
| P value | 4.13 × 1046 | 3.59 × 10−70 | 0.026 | 1.52 × 10−73 | 2.24 × 10−39 | 1.96 × 10−33 |
| Odds ratio | 1.73 | 2.82 | 1.11 | 1.95 | 2.42 | 1.75 |