Table 1 FVIII and FV mutants Residues .... | American Society of Hematology

Table 1

FVIII and FV mutants

Residues	FVIII mutants			FV mutants
	Spike 1	Spike 3		Spike 1	Spike 3	Spike 4
	2199/2200	2251/2252		2063/2064	2116/2117	2182/2183
Name	Amino acids		Name	Amino acids
FVIII_WT	Met Phe	Leu Leu	FV_WT	Trp Trp	Leu Ser	Gln Ser
FVIII_WW	Trp Trp*	Leu Leu	FV_MF	Met* Phe*	Leu Ser	Gln Ser
FVIII_LS	Met Phe	Leu Ser*	FV_LL	Trp Trp	Leu Leu*	Gln Ser
FVIII_WW/LS	Trp Trp*	Leu Ser*	FV_MF/LL	Met* Phe*	Leu Leu*	Gln Ser
			FV_MTTS/Y	Trp Trp	Met Thr (Thr Ser)*†	Gln Tyr

Residues	FVIII mutants			FV mutants
	Spike 1	Spike 3		Spike 1	Spike 3	Spike 4
	2199/2200	2251/2252		2063/2064	2116/2117	2182/2183
Name	Amino acids		Name	Amino acids
FVIII_WT	Met Phe	Leu Leu	FV_WT	Trp Trp	Leu Ser	Gln Ser
FVIII_WW	Trp Trp*	Leu Leu	FV_MF	Met* Phe*	Leu Ser	Gln Ser
FVIII_LS	Met Phe	Leu Ser*	FV_LL	Trp Trp	Leu Leu*	Gln Ser
FVIII_WW/LS	Trp Trp*	Leu Ser*	FV_MF/LL	Met* Phe*	Leu Leu*	Gln Ser
			FV_MTTS/Y	Trp Trp	Met Thr (Thr Ser)*†	Gln Tyr

WT denotes wild-type FVIII with the native sequence.

Amino acids that have been changed from the wild-type sequence.

Substitutions were also made for native residues Ser2118/Glu2119 (see Figure 5) for mutant FV_MTTS/Y.