IC50 values for AML cell lines
| Cell line . | Relevant cytogenetic/molecular data . | IC50, nM . |
|---|---|---|
| MV4-11 | XY, +8, +18, +19, −21, t(4;11)(q21;q23); FLT3-ITD+ | 100 |
| MOLM-13 | XY, +8, +13, del(8), ins(11;9)(q23;p22p23); FLT3-ITD+ | 100 |
| OCI-AML3 | X/XY, +1, +5, +8, t(1;18)(p11;q11), i(5p), del(13) (q13q21), dup(17)(q21q25); NPM1 mutation (type A) and the DNMT3A R882C mutation | 250 |
| Kasumi-1 | X, −Y, −9, −13, −16, t(8;21)(q22;q22); KIT mutation (Asn822Lys) | 500 |
| KG1a | X/XY, −4, +8, +8, −12, −17, −20, del(5)(q?11q?13), dup(7)(q12q33), del(7)(q22q35) | 250 |
| THP-1 | XY/XXY, −Y, +1, +3, +6, +6, −8, −13, −19, −22, −22, , del(1)(q42.2), del(6)(p21), t(9;11)(p22;q23) | 250 |
| Cell line . | Relevant cytogenetic/molecular data . | IC50, nM . |
|---|---|---|
| MV4-11 | XY, +8, +18, +19, −21, t(4;11)(q21;q23); FLT3-ITD+ | 100 |
| MOLM-13 | XY, +8, +13, del(8), ins(11;9)(q23;p22p23); FLT3-ITD+ | 100 |
| OCI-AML3 | X/XY, +1, +5, +8, t(1;18)(p11;q11), i(5p), del(13) (q13q21), dup(17)(q21q25); NPM1 mutation (type A) and the DNMT3A R882C mutation | 250 |
| Kasumi-1 | X, −Y, −9, −13, −16, t(8;21)(q22;q22); KIT mutation (Asn822Lys) | 500 |
| KG1a | X/XY, −4, +8, +8, −12, −17, −20, del(5)(q?11q?13), dup(7)(q12q33), del(7)(q22q35) | 250 |
| THP-1 | XY/XXY, −Y, +1, +3, +6, +6, −8, −13, −19, −22, −22, , del(1)(q42.2), del(6)(p21), t(9;11)(p22;q23) | 250 |