Table 4 Univariable outcome analyses... | American Society of Hematology

Table 4

Univariable outcome analyses according to secondary genetic abnormalities

Clinical end point	Genetic abnormality
	Trisomy 8			Trisomy 22			RAS			KIT			FLT3
	Present, n = 27	Absent, n = 141	P	Present, n = 31	Absent, n = 137	P	Mutation, n = 91	Wild type, n = 82	P	Mutation, n = 65	Wild type, n = 110	P	Mutation, n = 30	Wild type, n = 145	P
CR rate, %	89	91	.72	97	89	.31	90	90	.99	94	88	.29	83	92	.18
RFS			.89			.02			.83			.01			.71
Median, y	1.56	3.45		8.97	1.29		3.03	8.97		1.26	8.97		2.84	3.65
6-y RFS, %	50	49		70	43		49	50		38	60		49	50
95% CI	33-76	40-59		55-88	35-54		39-62	40-64		27-54	47-68		32-74	41-60
OS			.04			.12			.41			.49			.04
Median, y	NA	NA		NA	NA		NA	NA		NA	NA		NA	NA
6-y OS, %	53	69		79	64		64	69		61	70		51	70
95% CI	36-76	61-78		65-96	55-73		55-76	59-82		49-76	61-80		34-76	62-78

Clinical end point	Genetic abnormality
	Trisomy 8			Trisomy 22			RAS			KIT			FLT3
	Present, n = 27	Absent, n = 141	P	Present, n = 31	Absent, n = 137	P	Mutation, n = 91	Wild type, n = 82	P	Mutation, n = 65	Wild type, n = 110	P	Mutation, n = 30	Wild type, n = 145	P
CR rate, %	89	91	.72	97	89	.31	90	90	.99	94	88	.29	83	92	.18
RFS			.89			.02			.83			.01			.71
Median, y	1.56	3.45		8.97	1.29		3.03	8.97		1.26	8.97		2.84	3.65
6-y RFS, %	50	49		70	43		49	50		38	60		49	50
95% CI	33-76	40-59		55-88	35-54		39-62	40-64		27-54	47-68		32-74	41-60
OS			.04			.12			.41			.49			.04
Median, y	NA	NA		NA	NA		NA	NA		NA	NA		NA	NA
6-y OS, %	53	69		79	64		64	69		61	70		51	70
95% CI	36-76	61-78		65-96	55-73		55-76	59-82		49-76	61-80		34-76	62-78

NA indicates not applicable.