Table 1

FOXO1 mutations in DLBCL patients and cell lines

SampleCoordinateNucleotide changeAmino acid substitutionVerification resultZygosityMutation frequency*Variant frequency†
05-30349 chr13:40138349 T>A M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
95-16931 chr13:40138349 T>C M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-20828 chr13:40138349 T>C M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-31713 chr13:40138349 T>C M1V Somatic Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-23488 chr13:40138349 T>A M1L  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-31974 chr13:40138349 T>G M1L No germ line–validated mutation Heterozygous 2.2% (6/279) 23.1% (6/26) 
OCI-Ly1 chr13:40138349 T>A M1L Cell line–validated mutation Hemizygous   
Su-DHL-5
 		chr13:40138349
 		T>A
 		M1L
 		Cell line–validated mutation
 		Heterozygous
 
 
 
95-12860 chr13:40138279 G>A T24I  Heterozygous 0.72% (2/279) 7.7% (2/26) 
05-17793
 		chr13:40138280
 		T>C
 		T24A
 		Somatic
 		Heterozygous
 		0.72% (2/279)
 		7.7% (2/26)
 
06-19659 chr13:40138288 C>A R21L  Heterozygous 0.72% (2/279) 7.7% (2/26) 
01-15178 chr13:40138288 C>G R21P  Heterozygous 0.72% (2/279) 7.7% (2/26) 
Nu-DUL-1 chr13:40138288 C>G R21P Cell line–validated mutation Heterozygous  . 
Karpas422
 		chr13:40138289
 		G>A
 		R21C
 		Cell line–validated mutation
 		Heterozygous
 
 
 
04-11156 chr13:40138294 C>G R19P No germ line–validated mutation Heterozygous 0.72% (2/279) 7.7% (2/26) 
06-18547 chr13:40138295 G>A R19W Somatic Heterozygous 0.72% (2/279) 7.7% (2/26) 
DoHH2
 		chr13:40138295
 		G>A
 		R19W
 		Cell line–validated mutation
 		Heterozygous
 
 
 
06-27347 chr13:40137853 G>A A166V  Heterozygous 1.1% (3/279) 11.5% (3/26) 
00-18839 chr13:40137853 G>A A166V  Heterozygous 1.1% (3/279) 11.5% (3/26) 
02-16987
 		chr13:40137853
 		G>C
 		A166G
 
 		Heterozygous
 		1.1% (3/279)
 		11.5% (3/26)
 
75-50777 chr13:40137736 C>T S205N  Heterozygous 0.36% (1/279) 3.8% (1/26) 
Su-DHL-5 chr13:40137736 C>G S205T Cell line–validated mutation Heterozygous   
OCI-Ly1 chr13:40138322 T>C I10V Cell line–validated mutation Hemizygous   
06-28900 chr13:40138312 deletion D11  Heterozygous 0.36% (1/279) 3.8% (1/26) 
06-23907 chr13:40138068 deletion V94 (-VAAA) Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-17793 chr13:40137894 G>T S152R Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
99-25549 chr13:40137891 G>C S153R Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
95-11015 chr13:40137848 G>C L168V  Heterozygous 0.36% (1/279) 3.8% (1/26) 
03-23488 chr13:40137839 T>C K171E  Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-18695 chr13:40137802 A>G L183P  Heterozygous 0.36% (1/279) 3.8% (1/26) 
04-11650 chr13:40137793 A>G I186T  Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-30239 chr13:40032490 G>A L380F  Heterozygous 0.36% (1/279) 3.8% (1/26) 
03-25415 chr13:40032313 T>C I439V  Heterozygous 0.36% (1/279) 3.8% (1/26) 
8.6% (24/279)      9.3% (26/279) 100.00% 
SampleCoordinateNucleotide changeAmino acid substitutionVerification resultZygosityMutation frequency*Variant frequency†
05-30349 chr13:40138349 T>A M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
95-16931 chr13:40138349 T>C M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-20828 chr13:40138349 T>C M1V  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-31713 chr13:40138349 T>C M1V Somatic Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-23488 chr13:40138349 T>A M1L  Heterozygous 2.2% (6/279) 23.1% (6/26) 
03-31974 chr13:40138349 T>G M1L No germ line–validated mutation Heterozygous 2.2% (6/279) 23.1% (6/26) 
OCI-Ly1 chr13:40138349 T>A M1L Cell line–validated mutation Hemizygous   
Su-DHL-5
 		chr13:40138349
 		T>A
 		M1L
 		Cell line–validated mutation
 		Heterozygous
 
 
 
95-12860 chr13:40138279 G>A T24I  Heterozygous 0.72% (2/279) 7.7% (2/26) 
05-17793
 		chr13:40138280
 		T>C
 		T24A
 		Somatic
 		Heterozygous
 		0.72% (2/279)
 		7.7% (2/26)
 
06-19659 chr13:40138288 C>A R21L  Heterozygous 0.72% (2/279) 7.7% (2/26) 
01-15178 chr13:40138288 C>G R21P  Heterozygous 0.72% (2/279) 7.7% (2/26) 
Nu-DUL-1 chr13:40138288 C>G R21P Cell line–validated mutation Heterozygous  . 
Karpas422
 		chr13:40138289
 		G>A
 		R21C
 		Cell line–validated mutation
 		Heterozygous
 
 
 
04-11156 chr13:40138294 C>G R19P No germ line–validated mutation Heterozygous 0.72% (2/279) 7.7% (2/26) 
06-18547 chr13:40138295 G>A R19W Somatic Heterozygous 0.72% (2/279) 7.7% (2/26) 
DoHH2
 		chr13:40138295
 		G>A
 		R19W
 		Cell line–validated mutation
 		Heterozygous
 
 
 
06-27347 chr13:40137853 G>A A166V  Heterozygous 1.1% (3/279) 11.5% (3/26) 
00-18839 chr13:40137853 G>A A166V  Heterozygous 1.1% (3/279) 11.5% (3/26) 
02-16987
 		chr13:40137853
 		G>C
 		A166G
 
 		Heterozygous
 		1.1% (3/279)
 		11.5% (3/26)
 
75-50777 chr13:40137736 C>T S205N  Heterozygous 0.36% (1/279) 3.8% (1/26) 
Su-DHL-5 chr13:40137736 C>G S205T Cell line–validated mutation Heterozygous   
OCI-Ly1 chr13:40138322 T>C I10V Cell line–validated mutation Hemizygous   
06-28900 chr13:40138312 deletion D11  Heterozygous 0.36% (1/279) 3.8% (1/26) 
06-23907 chr13:40138068 deletion V94 (-VAAA) Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-17793 chr13:40137894 G>T S152R Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
99-25549 chr13:40137891 G>C S153R Somatic Heterozygous 0.36% (1/279) 3.8% (1/26) 
95-11015 chr13:40137848 G>C L168V  Heterozygous 0.36% (1/279) 3.8% (1/26) 
03-23488 chr13:40137839 T>C K171E  Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-18695 chr13:40137802 A>G L183P  Heterozygous 0.36% (1/279) 3.8% (1/26) 
04-11650 chr13:40137793 A>G I186T  Heterozygous 0.36% (1/279) 3.8% (1/26) 
05-30239 chr13:40032490 G>A L380F  Heterozygous 0.36% (1/279) 3.8% (1/26) 
03-25415 chr13:40032313 T>C I439V  Heterozygous 0.36% (1/279) 3.8% (1/26) 
8.6% (24/279)      9.3% (26/279) 100.00% 
*

Mutation frequency is the percentage of mutations calculated relative to all DLBCL patient samples.

†

Variant frequency, the percentage of mutations affecting that specific amino acid relative to all other mutations, is calculated based on the mutations found in DLBCL patients samples.

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