Table 1 Selectin ligand function and... | American Society of Hematology

Table 1

Selectin ligand function and leukocyte rolling in vitro and in vivo in St3gal4-, St3gal6-, and double-deficient mice compared with wild-type mice

	St3gal4^Δ/Δ	St3gal6^Δ/Δ	St3gal4^Δ/ΔSt3gal6^Δ/Δ
In vitro
P-selectin binding to neutrophils	↓	↓	↓↓
E-selectin binding to neutrophils	↓↓	↓	↓↓↓
L-selectin binding to secondary lymphatic tissues	↓	= − ↓	↓↓
P-selectin–dependent rolling (flow chamber)	↓ ¹⁶	↓	↓↓↓
E-selectin–dependent rolling (flow chamber)	↓ ¹⁶	=	↓↓↓
In vivo
P-selectin–dependent rolling	= ¹⁶	↓↓	↓↓
P-selectin–dependent rolling velocities (TNF-α–stimulated cremaster muscle)	= ¹⁶	=	=
E-selectin–dependent rolling	↓ ¹⁶	=	↓↓↓
E-selectin–dependent rolling velocities (TNF-α–stimulated cremaster muscle)	↑↑	=	↑↑
Lymphocyte homing (adoptive transfer of wild-type B and T cells)	↓	=	↓↓

	St3gal4^Δ/Δ	St3gal6^Δ/Δ	St3gal4^Δ/ΔSt3gal6^Δ/Δ
In vitro
P-selectin binding to neutrophils	↓	↓	↓↓
E-selectin binding to neutrophils	↓↓	↓	↓↓↓
L-selectin binding to secondary lymphatic tissues	↓	= − ↓	↓↓
P-selectin–dependent rolling (flow chamber)	↓ ¹⁶	↓	↓↓↓
E-selectin–dependent rolling (flow chamber)	↓ ¹⁶	=	↓↓↓
In vivo
P-selectin–dependent rolling	= ¹⁶	↓↓	↓↓
P-selectin–dependent rolling velocities (TNF-α–stimulated cremaster muscle)	= ¹⁶	=	=
E-selectin–dependent rolling	↓ ¹⁶	=	↓↓↓
E-selectin–dependent rolling velocities (TNF-α–stimulated cremaster muscle)	↑↑	=	↑↑
Lymphocyte homing (adoptive transfer of wild-type B and T cells)	↓	=	↓↓

The number of arrows indicates the magnitude of the change.

↑ indicates increases; ↓, decreases; =, no significant changes.