Table 1 Summary of whole-genome... | American Society of Hematology

Table 1

Summary of whole-genome sequencing metrics

	Normal*	Diagnostic*	Relapse 1*	Relapse 2*	sPCL†
Total reads	2 742 938 922	2 171 920 328	2 238 325 993	2 662 347 429	1 039 706 340
Aligned reads	2 035 868 820	1 551 256 330	1 577 742 203	1 878 505 981	968 454 017
Percent aligned, %	74.2	71.4	70.5	70.6	93.1
Coverage depth, raw	34	26	27	32	33
Coverage depth, duplicates removed	24	17	18	23	—
Total SNV	2 646 506	2 294 806	2 313 110	2 523 352	3 540 671
Somatic SNV	—	14 550	14 226	16 090	991 172
Somatic SNV unique to sample	—	9426	9089	10 088	983 125
Somatic SNV/MB	—	4.72	4.62	5.22	321.60
Small somatic indels	—	2828	2592	2230	548 404

	Normal*	Diagnostic*	Relapse 1*	Relapse 2*	sPCL†
Total reads	2 742 938 922	2 171 920 328	2 238 325 993	2 662 347 429	1 039 706 340
Aligned reads	2 035 868 820	1 551 256 330	1 577 742 203	1 878 505 981	968 454 017
Percent aligned, %	74.2	71.4	70.5	70.6	93.1
Coverage depth, raw	34	26	27	32	33
Coverage depth, duplicates removed	24	17	18	23	—
Total SNV	2 646 506	2 294 806	2 313 110	2 523 352	3 540 671
Somatic SNV	—	14 550	14 226	16 090	991 172
Somatic SNV unique to sample	—	9426	9089	10 088	983 125
Somatic SNV/MB	—	4.72	4.62	5.22	321.60
Small somatic indels	—	2828	2592	2230	548 404

PCL indicates plasma cell leukemia; —, not applicable; SNV, single-nucleotide variant; and MB, megabase.

SOLiD 50-bp single-end reads.

Illumina 101-bp paired-end reads.