Table 4

Genetic risk factors assessed for PE and DVT

Study design and NCountry where study was conductedAge, y, mean (SD)PE (95% CI)DVT (95% CI)DVT + PE (95% CI)
Blood group Case-control United States Mean (SD)    
    Ohira (2007)65  N total = 1500  63(10) total    
        Non-O vs O N cases = 492  63(10) cases OR = 2.0 (1.4-2.9)* OR = 1.4 (1.1-1.8)* — 
    Lijfering (unpublished data) Case-control The Netherlands 48, 18-72 OR = 1.7 (1.4-1.9)† OR = 2.3 (2.0-2.6)† OR = 2.4 (1.8-3.2)† 
 N total = 5317      
 N cases = 2377      
FVL Case-control The Netherlands Mean OR = 1.7 (1.3-2.2) OR = 4.5 (3.8-5.2) — 
    Van Stralen (2008)3  N total = 8170  48 total    
 N cases = 3313  49 cases    
    De Moerloose (2000)11  Case-control Switzerland 62 (19-99)* OR = 2.1 (0.68-5.5) OR = 3.4 (1.5-6.9) OR = 4.2 (1.5-10.3) 
 N total = 748      
 N cases = 3513      
    Margaglione (2000)10  Case-control Italy Median, range OR = 1.5 (0.74-3.1)‡ OR = 6.3 (4.5-9.0)‡ OR = 4.4 (2.8-7.0)‡ 
 N total = 1976  46 (18-86) cases    
 N cases = 647  37 (22-66) controls    
    Manten (1996)4  Case-control The Netherlands Mean OR = 3.3 (1.0-10.6)† OR = 6.9 (3.6-12.8)† — 
 N total = 753  42 cases    
 N cases = 279  44 controls    
    Martinelli (1997)7  Case-control Italy Median (range) OR = 1.8 (0.3-9.6)† OR = 10.0 (4.0-25.5)† OR = 5.5 (2.0-15.8)† 
 N total = 424  37 (15-67) total    
 N cases = 212  35 (15-66) cases    
    Baglin (1997)6  Case-control United Kingdom — OR = 4.8 (2.5-9.2)§ OR = 8.5 (4.8-14.8)§ — 
 N total = 1189      
 N cases = 678      
    Arsov (2006)5  Case-control Macedonia — OR = 2.6 (0.9-7.6) OR = 5.3 (2.6-10.8) — 
 N total = 390      
 N cases = 190      
    Boyanovsky (2001)9  Case-control Bulgaria Mean (range) OR = 1.4 (0.45-4.6)‖ OR = 5.1 (2.0-12.7)‖ OR = 3.9 (1.5-10.2)‖ 
 N total = 228  45 (21-68) cases    
 N cases = 128      
    González Ordóñez (2000)8  Case-control Spain Mean (range) OR = 1.3 (0.3-4.7) OR = 6.6 (3.1-14.1) OR = 5.2 (1.3-20.4) 
 N total = 584  57 (17-93) cases    
 N cases = 264      
    Okumus (2008)68  Case-control Turkey Mean, range OR = 1.8 (0.82-4.0) OR = 3.8 (1.6-9.1) OR = 4.3 (2.1-8.8) 
 N total = 382  53 (16-88) cases    
 N cases = 191  51 (16-88) controls    
Prothrombin G20210A Case-control The Netherlands Mean OR = 2.3 (1.5-3.3) OR = 3.2 (2.4-4.2) — 
    Van Stralen (2008)3  N total = 8170  48 total    
 N cases = 3313  49 cases    
    Margaglione (2000)10  Case-control Italy Median, range OR = 2.1 (1.1-4.1)‡ OR = 3.6 (2.4-5.4)‡ OR = 3.0 (1.8-5.1)‡ 
 N total = 1976  46 (18-86) cases    
 N cases = 647  37 (22-66) controls    
    Boyanovsky (2001)9  Case-control Bulgaria Mean (range) OR = 1.5 (0.41-5.3)‖ OR = 3.3 (1.1-9.6)‖ OR = 3.0 (1.0-9.0)‖ 
 N total = 228  45 (21-68) cases    
 N cases = 128      
    González Ordóñez (2000)8  Case-control Spain Mean (range) OR = 2.4 (0.9-6.1) OR = 2.5 (1.1-5.4) OR = 5.6 (1.6-18.9) 
 N total = 584  57 (17-93) cases    
 N cases = 264      
    Okumus (2008)68  Case-control Turkey Mean, range OR = 1.6 (0.45-5.9) OR = 0.86 (0.10-7.3) OR = 3.7 (1.3-11.2) 
 N total = 382  53 (16-88) cases    
 N cases = 191  51(16-88) controls    
    De Moerloose (2000)11  Case-control Switzerland 62 (19-99)* OR = 0.90 (0.10-3.8) OR = 0.61 (0.07-2.7) OR = 2.6 (0.62-8.2) 
 N total = 748      
 N cases = 182      
    Weischer (2010)69  Cohort Denmark Median, IQR HR = 1.7 (0.6-4.5)* HR = 0.8 (0.3-2.5)* — 
 N total = 9231  52 (45-57)    
   for all VT patients    
Study design and NCountry where study was conductedAge, y, mean (SD)PE (95% CI)DVT (95% CI)DVT + PE (95% CI)
Blood group Case-control United States Mean (SD)    
    Ohira (2007)65  N total = 1500  63(10) total    
        Non-O vs O N cases = 492  63(10) cases OR = 2.0 (1.4-2.9)* OR = 1.4 (1.1-1.8)* — 
    Lijfering (unpublished data) Case-control The Netherlands 48, 18-72 OR = 1.7 (1.4-1.9)† OR = 2.3 (2.0-2.6)† OR = 2.4 (1.8-3.2)† 
 N total = 5317      
 N cases = 2377      
FVL Case-control The Netherlands Mean OR = 1.7 (1.3-2.2) OR = 4.5 (3.8-5.2) — 
    Van Stralen (2008)3  N total = 8170  48 total    
 N cases = 3313  49 cases    
    De Moerloose (2000)11  Case-control Switzerland 62 (19-99)* OR = 2.1 (0.68-5.5) OR = 3.4 (1.5-6.9) OR = 4.2 (1.5-10.3) 
 N total = 748      
 N cases = 3513      
    Margaglione (2000)10  Case-control Italy Median, range OR = 1.5 (0.74-3.1)‡ OR = 6.3 (4.5-9.0)‡ OR = 4.4 (2.8-7.0)‡ 
 N total = 1976  46 (18-86) cases    
 N cases = 647  37 (22-66) controls    
    Manten (1996)4  Case-control The Netherlands Mean OR = 3.3 (1.0-10.6)† OR = 6.9 (3.6-12.8)† — 
 N total = 753  42 cases    
 N cases = 279  44 controls    
    Martinelli (1997)7  Case-control Italy Median (range) OR = 1.8 (0.3-9.6)† OR = 10.0 (4.0-25.5)† OR = 5.5 (2.0-15.8)† 
 N total = 424  37 (15-67) total    
 N cases = 212  35 (15-66) cases    
    Baglin (1997)6  Case-control United Kingdom — OR = 4.8 (2.5-9.2)§ OR = 8.5 (4.8-14.8)§ — 
 N total = 1189      
 N cases = 678      
    Arsov (2006)5  Case-control Macedonia — OR = 2.6 (0.9-7.6) OR = 5.3 (2.6-10.8) — 
 N total = 390      
 N cases = 190      
    Boyanovsky (2001)9  Case-control Bulgaria Mean (range) OR = 1.4 (0.45-4.6)‖ OR = 5.1 (2.0-12.7)‖ OR = 3.9 (1.5-10.2)‖ 
 N total = 228  45 (21-68) cases    
 N cases = 128      
    González Ordóñez (2000)8  Case-control Spain Mean (range) OR = 1.3 (0.3-4.7) OR = 6.6 (3.1-14.1) OR = 5.2 (1.3-20.4) 
 N total = 584  57 (17-93) cases    
 N cases = 264      
    Okumus (2008)68  Case-control Turkey Mean, range OR = 1.8 (0.82-4.0) OR = 3.8 (1.6-9.1) OR = 4.3 (2.1-8.8) 
 N total = 382  53 (16-88) cases    
 N cases = 191  51 (16-88) controls    
Prothrombin G20210A Case-control The Netherlands Mean OR = 2.3 (1.5-3.3) OR = 3.2 (2.4-4.2) — 
    Van Stralen (2008)3  N total = 8170  48 total    
 N cases = 3313  49 cases    
    Margaglione (2000)10  Case-control Italy Median, range OR = 2.1 (1.1-4.1)‡ OR = 3.6 (2.4-5.4)‡ OR = 3.0 (1.8-5.1)‡ 
 N total = 1976  46 (18-86) cases    
 N cases = 647  37 (22-66) controls    
    Boyanovsky (2001)9  Case-control Bulgaria Mean (range) OR = 1.5 (0.41-5.3)‖ OR = 3.3 (1.1-9.6)‖ OR = 3.0 (1.0-9.0)‖ 
 N total = 228  45 (21-68) cases    
 N cases = 128      
    González Ordóñez (2000)8  Case-control Spain Mean (range) OR = 2.4 (0.9-6.1) OR = 2.5 (1.1-5.4) OR = 5.6 (1.6-18.9) 
 N total = 584  57 (17-93) cases    
 N cases = 264      
    Okumus (2008)68  Case-control Turkey Mean, range OR = 1.6 (0.45-5.9) OR = 0.86 (0.10-7.3) OR = 3.7 (1.3-11.2) 
 N total = 382  53 (16-88) cases    
 N cases = 191  51(16-88) controls    
    De Moerloose (2000)11  Case-control Switzerland 62 (19-99)* OR = 0.90 (0.10-3.8) OR = 0.61 (0.07-2.7) OR = 2.6 (0.62-8.2) 
 N total = 748      
 N cases = 182      
    Weischer (2010)69  Cohort Denmark Median, IQR HR = 1.7 (0.6-4.5)* HR = 0.8 (0.3-2.5)* — 
 N total = 9231  52 (45-57)    
   for all VT patients    
*

Adjusted for age.

†

Adjusted for age and sex.

‡

Calculated from Table 3 of the original article.

§

Calculated with heterozygous and homozygous FVL carriers pooled from the original article.

‖

Calculated from Table 1 of the original article.

Calculated from Tables 2 and 4 of the original article.

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