B-cell receptor signaling in CLL cells compared with normal B cells
| Characteristic . | CLL cells . |
|---|---|
| sIg expression | Low |
| CD79b expression | Low |
| Response to antigen stimulation | Variable |
| Syk/Lyn/Btk expression | Elevated |
| PI3K p110δ expression | Normal |
| PI3K kinase activity | Elevated |
| Calcium flux | Variable/generally low |
| Characteristic . | CLL cells . |
|---|---|
| sIg expression | Low |
| CD79b expression | Low |
| Response to antigen stimulation | Variable |
| Syk/Lyn/Btk expression | Elevated |
| PI3K p110δ expression | Normal |
| PI3K kinase activity | Elevated |
| Calcium flux | Variable/generally low |