Temporal correlation of 17p13 deletion and TP53 mutation
Patient . | Sample 1 . | Sample 2 . | Sample 3 . | Sample 4 . | Sample 5 . |
---|---|---|---|---|---|
MC0518 | 1× del not tested (24) | 2× del (36) | |||
MC0004 | 1× del no mutation (30) | 1× del + N239K (35) | |||
MC0678 | 1× del no mutation (36) | 1× del no mutation (60) | |||
MC0026 | 1× del not tested (51) | 1× del + T125-M133del (76) | |||
MMRC0206* | 2× del (33) | 1× del (77) | |||
MC1130† | No del WGS (34) | No del WGS (37) | No del WGS (36) | 2× del (63) | 2× del WGS (63) |
Patient . | Sample 1 . | Sample 2 . | Sample 3 . | Sample 4 . | Sample 5 . |
---|---|---|---|---|---|
MC0518 | 1× del not tested (24) | 2× del (36) | |||
MC0004 | 1× del no mutation (30) | 1× del + N239K (35) | |||
MC0678 | 1× del no mutation (36) | 1× del no mutation (60) | |||
MC0026 | 1× del not tested (51) | 1× del + T125-M133del (76) | |||
MMRC0206* | 2× del (33) | 1× del (77) | |||
MC1130† | No del WGS (34) | No del WGS (37) | No del WGS (36) | 2× del (63) | 2× del WGS (63) |
Numbers in parentheses indicate the number of copy number abnormalities at each time point.
These samples, in particular the second sample, are not available for testing and unfortunately were not tested as part of the Multiple Myeloma Research Consortium Genomics Initiative whole genome sequencing project.
MC1130 was sequenced with both SOLiD and HiSeq Whole Genome Sequencing (WGS) at the time points indicated by WGS (Egan et al29 ). No mutations were seen in TP53 at any time.