Patients studied serially for CNAs
| Patient . | Cyto risk . | Ploidy . | Sample 1 CNA . | Sample 2 CNA . | Shared CNA . | New CNA . | Lost CNA . | Time, mo . | Treatments . |
|---|---|---|---|---|---|---|---|---|---|
| MC0002 | Low | HD | 13 | 13 | 13 | 0 | 0 | 10 | None |
| MC1059 | Low | HD | 19 | 19 | 19 | 0 | 0 | 12 | MPT |
| MC1272 | Low | HD | 11 | 11 | 11 | 0 | 0 | 38 | Rd + HDT-Tx |
| MMRC0161 | Low | HD | 13 | 13 | 13 | 0 | 0 | 8 | Bort + Temsirolimus |
| MC0391 | Low | HD | 11 | 11 | 11 | 0 | 0 | 19 | Bort + HDT-tx |
| MC0085 | Low | HD | 33 | 33 | 33 | 0 | 0 | 36 | MP |
| MMRC0359 | Low | NHD | 21 | 21 | 21 | 0 | 0 | 1 | Radiation |
| MMRC0155 | Low | NHD | 13 | 13 | 13 | 0 | 0 | 15 | Radiation | TD |
| MC1387 | NA | NHD | 14 | 14 | 14 | 0 | 0 | 5 | AUY922 | Cyclo-Len-Pred |
| MC0506 | High | NHD | 21 | 21 | 21 | 0 | 0 | 24 | MPR | MPV |
| MC1484 | High | NHD | 11 | 12 | 11 | 1 | 0 | 17 | Pd |
| MMRC0395 | Low | HD | 35 | 36 | 35 | 1 | 0 | 3 | DPCE + HDT-Tx |
| MMRC0191 | Low | HD | 31 | 33 | 31 | 2 | 0 | 22 | 5 Regimens |
| MC0453 | Low | HD | 8 | 10 | 8 | 2 | 0 | 43 | TD + HDT-Tx | TD | Bort |
| MC0007 | Low | NHD | 3 | 11 | 3 | 8 | 0 | 20 | Len | Pd |
| MC0518 | High | NHD | 24 | 36 | 24 | 12 | 0 | 6 | Dex |
| MC0134 | Low | HD | 9 | 10 | 5 | 5 | 4 | 12 | None |
| MC0004 | High | HD | 30 | 35 | 28 | 7 | 2 | 21 | Rd |
| MC0496 | Low | HD | 11 | 16 | 8 | 8 | 3 | 23 | Dex + HDT-Tx |
| MMRC0154 | Low | HD | 7 | 19 | 6 | 12 | 1 | 17 | Dex + HDT-Tx |
| MC0005 | Low | HD | 13 | 28 | 12 | 15 | 1 | 65 | Rd |
| MC0003 | Low | NHD | 11 | 14 | 4 | 10 | 7 | 22 | MPR | VD | CyBorD | Rd |
| MC0678 | High | NHD | 36 | 60 | 35 | 25 | 1 | 6 | Dex + HDT-Tx |
| MC1472 | Low | NHD | 10 | 25 | 4 | 21 | 6 | 19 | CyBorD + HDT-Tx |
| MC0026 | High | NHD | 51 | 76 | 46 | 30 | 5 | 10 | VAD + HDT-Tx |
| MC0474 | Low | HD | 26 | 31 | 7 | 24 | 19 | 29 | Dex | Rd + HDT-Tx |
| MMRC0206 | High | NHD | 33 | 77 | 30 | 47 | 3 | 20 | Unknown |
| MC1130 | High | NHD | 34 | 37 | 5 | 32 | 29 | 21 | Rd |
| Patient . | Cyto risk . | Ploidy . | Sample 1 CNA . | Sample 2 CNA . | Shared CNA . | New CNA . | Lost CNA . | Time, mo . | Treatments . |
|---|---|---|---|---|---|---|---|---|---|
| MC0002 | Low | HD | 13 | 13 | 13 | 0 | 0 | 10 | None |
| MC1059 | Low | HD | 19 | 19 | 19 | 0 | 0 | 12 | MPT |
| MC1272 | Low | HD | 11 | 11 | 11 | 0 | 0 | 38 | Rd + HDT-Tx |
| MMRC0161 | Low | HD | 13 | 13 | 13 | 0 | 0 | 8 | Bort + Temsirolimus |
| MC0391 | Low | HD | 11 | 11 | 11 | 0 | 0 | 19 | Bort + HDT-tx |
| MC0085 | Low | HD | 33 | 33 | 33 | 0 | 0 | 36 | MP |
| MMRC0359 | Low | NHD | 21 | 21 | 21 | 0 | 0 | 1 | Radiation |
| MMRC0155 | Low | NHD | 13 | 13 | 13 | 0 | 0 | 15 | Radiation | TD |
| MC1387 | NA | NHD | 14 | 14 | 14 | 0 | 0 | 5 | AUY922 | Cyclo-Len-Pred |
| MC0506 | High | NHD | 21 | 21 | 21 | 0 | 0 | 24 | MPR | MPV |
| MC1484 | High | NHD | 11 | 12 | 11 | 1 | 0 | 17 | Pd |
| MMRC0395 | Low | HD | 35 | 36 | 35 | 1 | 0 | 3 | DPCE + HDT-Tx |
| MMRC0191 | Low | HD | 31 | 33 | 31 | 2 | 0 | 22 | 5 Regimens |
| MC0453 | Low | HD | 8 | 10 | 8 | 2 | 0 | 43 | TD + HDT-Tx | TD | Bort |
| MC0007 | Low | NHD | 3 | 11 | 3 | 8 | 0 | 20 | Len | Pd |
| MC0518 | High | NHD | 24 | 36 | 24 | 12 | 0 | 6 | Dex |
| MC0134 | Low | HD | 9 | 10 | 5 | 5 | 4 | 12 | None |
| MC0004 | High | HD | 30 | 35 | 28 | 7 | 2 | 21 | Rd |
| MC0496 | Low | HD | 11 | 16 | 8 | 8 | 3 | 23 | Dex + HDT-Tx |
| MMRC0154 | Low | HD | 7 | 19 | 6 | 12 | 1 | 17 | Dex + HDT-Tx |
| MC0005 | Low | HD | 13 | 28 | 12 | 15 | 1 | 65 | Rd |
| MC0003 | Low | NHD | 11 | 14 | 4 | 10 | 7 | 22 | MPR | VD | CyBorD | Rd |
| MC0678 | High | NHD | 36 | 60 | 35 | 25 | 1 | 6 | Dex + HDT-Tx |
| MC1472 | Low | NHD | 10 | 25 | 4 | 21 | 6 | 19 | CyBorD + HDT-Tx |
| MC0026 | High | NHD | 51 | 76 | 46 | 30 | 5 | 10 | VAD + HDT-Tx |
| MC0474 | Low | HD | 26 | 31 | 7 | 24 | 19 | 29 | Dex | Rd + HDT-Tx |
| MMRC0206 | High | NHD | 33 | 77 | 30 | 47 | 3 | 20 | Unknown |
| MC1130 | High | NHD | 34 | 37 | 5 | 32 | 29 | 21 | Rd |
Ploidy categories hyperdiploid (HD) and non-hyperdiploid (NHD) are indicated. Different treatment combinations used separately are spaced and separated by a vertical bar (|).
MPT indicates melphalan, prednisone, and thalidomide; Rd, lenalidomide with low-dose dexamethasone; HDT-Tx, high-dose melphalan followed by autologous transplantation; Bort, bortezomib alone; MP, melphalan and prednisone; TD, thalidomide and dexamethasone; MPR, melphalan, prednisone, and lenalidomide; MPV, melphalan, prednisone, and bortezomib; Pd, pomalidomide with low-dose dexamethasone; DPCE, cyclophosphamide, dexamethasone, etoposide, and cisplatin; VD, bortezomib with dexamethasone; CyBorD, cyclophosphamide, bortezomib, and dexamethasone; VAD, vincristine, Adriamycin, and dexamethasone; and NA, not available.