Table 5

Pharmacokinetic parameters of KPT-251 after a PO dose of 50 mg/kg in CD1 mice

PK parametersUnitEstimated value
Tmax hr 2.00 
Cmax ng/mL 1400 
Terminal t1/2 hr 4.43 
AUClast hr×ng/mL 15 400 
AUCINF hr×ng/mL 15 400 
PK parametersUnitEstimated value
Tmax hr 2.00 
Cmax ng/mL 1400 
Terminal t1/2 hr 4.43 
AUClast hr×ng/mL 15 400 
AUCINF hr×ng/mL 15 400 
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