Individual and mean plasma concentration-time data of KPT-251 after a PO dose of 50 mg/kg in CD1 mice
| Dose (mg/kg) . | Dose route . | Sampling time, h . | Plasma concentration (ng/mL) Individual . | Mean . | SD . | CV(%) . | ||
|---|---|---|---|---|---|---|---|---|
| 50 | PO | 0.5 | 1610 | 620 | 982 | 1071 | 501 | 46.8 |
| 2 | 1150 | 1720 | 1320 | 1397 | 293 | 21.0 | ||
| LLOQ = 1 ng/mL | 4 | 1080 | 559 | 940 | 860 | 270 | 31.4 | |
| 24 | 9.69 | 56.2 | 386 | 151 | 205 | 136 | ||
| 36 | 2.74 | 4.97 | BQL | 3.86 | 1.58 | N/A | ||
| Dose (mg/kg) . | Dose route . | Sampling time, h . | Plasma concentration (ng/mL) Individual . | Mean . | SD . | CV(%) . | ||
|---|---|---|---|---|---|---|---|---|
| 50 | PO | 0.5 | 1610 | 620 | 982 | 1071 | 501 | 46.8 |
| 2 | 1150 | 1720 | 1320 | 1397 | 293 | 21.0 | ||
| LLOQ = 1 ng/mL | 4 | 1080 | 559 | 940 | 860 | 270 | 31.4 | |
| 24 | 9.69 | 56.2 | 386 | 151 | 205 | 136 | ||
| 36 | 2.74 | 4.97 | BQL | 3.86 | 1.58 | N/A | ||
N/A indicates not available.