Pharmacokinetic properties
| PK parameters . | KPT-185 . | KPT-251 . | ||
|---|---|---|---|---|
| PO-10 mg/kg . | IV-5 mg/kg . | PO-10 mg/kg . | IV-5 mg/kg . | |
| Cmax (ng/ml)* | 4.2 | 2267 | 439 | 4192 |
| Tmax, h | 0.083 | NA | 0.5 | NA |
| T1/2, h | NA | 0.37 | 3.83 | 1.07 |
| AUC, h × ng/mL | NA | 208 | 1590 | 1370 |
| Bioavailability (%) | NA | 56 | ||
| PK parameters . | KPT-185 . | KPT-251 . | ||
|---|---|---|---|---|
| PO-10 mg/kg . | IV-5 mg/kg . | PO-10 mg/kg . | IV-5 mg/kg . | |
| Cmax (ng/ml)* | 4.2 | 2267 | 439 | 4192 |
| Tmax, h | 0.083 | NA | 0.5 | NA |
| T1/2, h | NA | 0.37 | 3.83 | 1.07 |
| AUC, h × ng/mL | NA | 208 | 1590 | 1370 |
| Bioavailability (%) | NA | 56 | ||
C0 for IV dosing.