Mean number of CNAs per patient detected by paired SNP array analysis of 144 CLL patients
| . | All CNAs . | CNAs detected beyond FISH analysis . |
|---|---|---|
| All patients (n = 144) | 1.81 | 0.72 |
| IGHV mutated (n = 61) | 1.85 | 0.70 |
| IGHV unmutated (n = 79) | 1.80 | 0.75 |
| No aberration (n = 28) | 0.86 | 0.86 |
| del(13)(q14) as sole abnormality (n = 49) | 1.49 | 0.31 |
| trisomy 12 (n = 19) | 2.11 | 0.84 |
| del(11)(q22.3) (n = 33) | 2.48 | 0.91 |
| del(17)(p13)/TP53 mutated (n = 15) | 2.80 | 1.27 |
| Low-risk patients (n = 96) | 1.40 | 0.55 |
| High-risk patients (n = 48) | 2.61 | 1.06 |
| . | All CNAs . | CNAs detected beyond FISH analysis . |
|---|---|---|
| All patients (n = 144) | 1.81 | 0.72 |
| IGHV mutated (n = 61) | 1.85 | 0.70 |
| IGHV unmutated (n = 79) | 1.80 | 0.75 |
| No aberration (n = 28) | 0.86 | 0.86 |
| del(13)(q14) as sole abnormality (n = 49) | 1.49 | 0.31 |
| trisomy 12 (n = 19) | 2.11 | 0.84 |
| del(11)(q22.3) (n = 33) | 2.48 | 0.91 |
| del(17)(p13)/TP53 mutated (n = 15) | 2.80 | 1.27 |
| Low-risk patients (n = 96) | 1.40 | 0.55 |
| High-risk patients (n = 48) | 2.61 | 1.06 |
Genomic aberrations are grouped according to the hierarchical model.1 High-risk is defined by the presence of del(11)(q22.3), del(17)(p13), and/or TP53 mutation; low-risk by the absence of these alterations.