Correlation of CLL risk factors and AID expression
| Parameter . | Cox regression proportional hazard . | |||||
|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | |||||
| P . | HR . | 95% CI . | P . | HR . | 95% CI . | |
| Unmutated IGHV | .0058 | 3.991 | 1.494-10.661 | .0191 | 3.260 | 1.213-8.760 |
| CD38+ | .0855 | 2.034 | 0.906-4.567 | |||
| ZAP-70+ | .0046 | 3.267 | 1.440-7.413 | .0653 | 2.192 | 0.951-5.049 |
| High-risk aberrations | .0612 | 2.172 | 0.964-4.892 | |||
| AID+ | .0055 | 3.080 | 1.392-6.817 | .0244 | 2.524 | 1.127-5.651 |
| Parameter . | Cox regression proportional hazard . | |||||
|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | |||||
| P . | HR . | 95% CI . | P . | HR . | 95% CI . | |
| Unmutated IGHV | .0058 | 3.991 | 1.494-10.661 | .0191 | 3.260 | 1.213-8.760 |
| CD38+ | .0855 | 2.034 | 0.906-4.567 | |||
| ZAP-70+ | .0046 | 3.267 | 1.440-7.413 | .0653 | 2.192 | 0.951-5.049 |
| High-risk aberrations | .0612 | 2.172 | 0.964-4.892 | |||
| AID+ | .0055 | 3.080 | 1.392-6.817 | .0244 | 2.524 | 1.127-5.651 |
Individual Cox regressions were used to examine the association between each factor and TFT on 83 CLL patients with data for all parameters listed. Factors were then included in a multivariable Cox proportional hazards model to examine the joint effects of those factors on TFT. Best subsets selection was used to select the final multivariate model. Factors that did not fit the multivariate best model are indicated by “-”. High-risk aberrations (+), that is, patient cells having at least 1 of the 3 aberrations 11q22.3, 12-CEN, or 17p12.1, were compared against those with 0 of 3.
HR indicates hazard ratio; and CI, confidence interval.