Sex | n (%) |
Male | 14 (64) |
Female | 8 (36) |
Race/ethnicity | |
White/non-Hispanic or unknown | 13 (59) |
White/Hispanic | 7 (32) |
Asian/non-Hispanic | 2 (9) |
Median age, y (range) | 12 (1.3-22.3) |
Lineage | |
B-precursor ALL | 20 (91) |
T-cell ALL | 2 (9) |
Treatment attempts | |
Failed 2 regimes | 17 (77) |
Failed 3 regimes | 5 (23) |
Previous BMT | |
None | 18 (82) |
Yes | 4 (18) |
BM (at study entry) M3 | 22 (100) |
Treatment data | |
Bortezomib: 4 planned doses | 22 (100) |
Completed therapy | 19 (86) |
Induction death | 3 (14) |
BM aplasia | None |
Days to ANC > 750/μL, median (range) | 38 (27-48) |
Days to platelets > 75 000/μL, median (range) | 35 (27-41) |
Sex | n (%) |
Male | 14 (64) |
Female | 8 (36) |
Race/ethnicity | |
White/non-Hispanic or unknown | 13 (59) |
White/Hispanic | 7 (32) |
Asian/non-Hispanic | 2 (9) |
Median age, y (range) | 12 (1.3-22.3) |
Lineage | |
B-precursor ALL | 20 (91) |
T-cell ALL | 2 (9) |
Treatment attempts | |
Failed 2 regimes | 17 (77) |
Failed 3 regimes | 5 (23) |
Previous BMT | |
None | 18 (82) |
Yes | 4 (18) |
BM (at study entry) M3 | 22 (100) |
Treatment data | |
Bortezomib: 4 planned doses | 22 (100) |
Completed therapy | 19 (86) |
Induction death | 3 (14) |
BM aplasia | None |
Days to ANC > 750/μL, median (range) | 38 (27-48) |
Days to platelets > 75 000/μL, median (range) | 35 (27-41) |
ALL indicates acute lymphoblastic leukemia; ANC, absolute neutrophil count; BMT, BM transplantation; and M3, > 25% BM blasts.