NK- and T-cell populations and HLA-C typing for n = 32 patients in the study
Dose . | Patient no. . | Peripheral T lymphocytes . | Peripheral NK lymphocytes . | NK/T . | HLA-C KIR ligand . | HLA-C KIR ligand . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All . | IPH2101(+) . | All . | IPH2101(+) . | |||||||||
% . | abs/μL . | % . | abs/μL . | % . | abs/μL . | % . | abs/μL . | |||||
0.0003 | 1 | 58.2 | 606 | 20.9 | 127 | 28.6 | 295 | 58.7 | 173 | 1.4 | 05xx C2 | 07xx C1 |
0.003 | 2 | 80.1 | 1529 | 6.2 | 95 | 6.2 | 121 | 61.6 | 75 | 0.8 | 04xx C2 | 15xx C2 |
0.003 | 3 | 87.3 | 1955 | 0.8 | 16 | 7.9 | 185 | 23.5 | 43 | 2.8 | 01xx C1 | 07xx C1 |
0.015 | 4 | 77 | 907 | 11.7 | 106 | 23.9 | 275 | 68.6 | 189 | 1.8 | 04xx C2 | 07xx C1 |
0.015 | 5 | 59.5 | 970 | 6.9 | 67 | 25.7 | 380 | 46 | 175 | 2.6 | 07xx C1 | |
0.015 | 6 | 63.6 | 1732 | 2.2 | 38 | 11.9 | 324 | 41.8 | 135 | 3.6 | 04xx C2 | |
0.075 | 7 | 75.7 | 636 | 3.4 | 22 | 14.5 | 146 | 45 | 66 | 3.0 | 07xx C1 | 12xx C1 |
0.075 | 8 | 70.4 | 1072 | 0.4 | 4 | 12.1 | 182 | 55.4 | 101 | 23.5 | 04xx C2 | 15xx C2 |
0.075 | 9 | 57.2 | 927 | 1.9 | 18 | 5.1 | 109 | 33 | 36 | 2.0 | 03xx C1 | |
0.3 | 10 | 55.3 | 538 | 1.2 | 6 | 20.2 | 208 | 50 | 104 | 16.1 | 01xx C1 | 05xx C2 |
0.3 | 11 | 81.7 | 1222 | 3.2 | 39 | 6.9 | 117 | 18.8 | 22 | 0.6 | 01xx C1 | 07xx C1 |
1 | 12 | 76.8 | 1186 | 0.5 | 6 | 6.6 | 124 | 64.4 | 80 | 13.5 | 03xx C1 | 04xx C2 |
1 | 13 | 77.9 | 1033 | 12.5 | 129 | 14.8 | 199 | 51 | 101 | 0.8 | 07xx C1 | |
3 | 14 | 85.2 | 1046 | 3.1 | 32 | 5.7 | 71 | 35.5 | 25 | 0.8 | 03xx C1 | 07xx C1 |
3 | 15 | 51.1 | 631 | 1.9 | 12 | 21.6 | 295 | 45 | 133 | 11.1 | 04xx C2 | 12xx C1 |
3 | 16 | 55 | 911 | 0.6 | 5 | 17.9 | 300 | 43.7 | 131 | 24.0 | 03xx C1 | 04xx C2 |
3 | 17 | 49.7 | 653 | 1.8 | 12 | 21.4 | 287 | 28.8 | 83 | 7.0 | 05xx C2 | |
3 | 18 | 67.7 | 1147 | 0.6 | 7 | 17.5 | 338 | 41 | 139 | 20.1 | 07xx C1 | 15xx C2 |
3 | 19 | 72.5 | 1658 | 1.4 | 23 | 8.9 | 214 | 43.6 | 93 | 4.0 | 02xx C2 | 03xx C1 |
0.0003 | 20 | 72.3 | 664 | 2.3 | 15 | 11.6 | 108 | 22 | 24 | 1.6 | 03xx C1 | 06xx C1 |
0.0003 | 21 | 45.4 | 1137 | 3.5 | 40 | 15.5 | 368 | 78.7 | 290 | 7.3 | 03xx C1 | 04xx C2 |
0.0003 | 22 | 57.8 | 625 | 3.8 | 24 | 6.7 | 72 | 39 | 28 | 1.2 | 05xx C2 | 12xx C1 |
0.003 | 23 | 23.4 | 305 | 2.8 | 9 | 10.2 | 120 | 46.9 | 56 | 6.6 | 04xx C2 | 05xx C2 |
0.075 | 24 | 83.7 | 689 | 0.7 | 5 | 12.4 | 102 | 60.6 | 62 | 12.8 | 01xx C1 | |
0.075 | 25 | 75.5 | 435 | 18.9 | 82 | 17.6 | 95 | 38.7 | 37 | 0.4 | 04xx C2 | 06xx C1 |
0.075 | 26 | 47 | 580 | 5.3 | 31 | 12.4 | 139 | 39.7 | 55 | 1.8 | 01xx C1 | 07xx C1 |
0.3 | 27 | 56.1 | 1120 | 3.4 | 38 | 32.3 | 699 | 39.4 | 275 | 7.2 | 07xx C1 | 12xx C1 |
3 | 28 | 77.1 | 413 | 1.4 | 6 | 13.4 | 73 | 40.2 | 29 | 5.1 | 01xx C1 | 03xx C1 |
1 | 29 | 77.5 | 1652 | 1.6 | 26 | 6.8 | 163 | 48.6 | 79 | 3.0 | 01xx C1 | 16xx C1 |
3 | 30 | 86.3 | 1803 | 2.3 | 41 | 6.4 | 145 | 48.4 | 70 | 1.7 | 04xx C2 | 07xx C2 |
3 | 31 | 45.5 | 446 | 1.6 | 7 | 34.6 | 309 | 20.1 | 62 | 8.7 | 04xx C2 | |
3 | 32 | 60.6 | 546 | 1.1 | 6 | 12.8 | 116 | 48.6 | 56 | 9.4 | 12xx C1 | 16xx C1 |
Mean | 65.9 | 962 | 4 | 34 | 14.7 | 209 | 44.6 | 95 | 6.4 | |||
Median | 69.1 | 919 | 2.3 | 22 | 12.6 | 173 | 44.4 | 77 | 3.3 | |||
SD | 15.1 | 451 | 5.1 | 36 | 8.0 | 130 | 13.9 | 67 | 6.7 |
Dose . | Patient no. . | Peripheral T lymphocytes . | Peripheral NK lymphocytes . | NK/T . | HLA-C KIR ligand . | HLA-C KIR ligand . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All . | IPH2101(+) . | All . | IPH2101(+) . | |||||||||
% . | abs/μL . | % . | abs/μL . | % . | abs/μL . | % . | abs/μL . | |||||
0.0003 | 1 | 58.2 | 606 | 20.9 | 127 | 28.6 | 295 | 58.7 | 173 | 1.4 | 05xx C2 | 07xx C1 |
0.003 | 2 | 80.1 | 1529 | 6.2 | 95 | 6.2 | 121 | 61.6 | 75 | 0.8 | 04xx C2 | 15xx C2 |
0.003 | 3 | 87.3 | 1955 | 0.8 | 16 | 7.9 | 185 | 23.5 | 43 | 2.8 | 01xx C1 | 07xx C1 |
0.015 | 4 | 77 | 907 | 11.7 | 106 | 23.9 | 275 | 68.6 | 189 | 1.8 | 04xx C2 | 07xx C1 |
0.015 | 5 | 59.5 | 970 | 6.9 | 67 | 25.7 | 380 | 46 | 175 | 2.6 | 07xx C1 | |
0.015 | 6 | 63.6 | 1732 | 2.2 | 38 | 11.9 | 324 | 41.8 | 135 | 3.6 | 04xx C2 | |
0.075 | 7 | 75.7 | 636 | 3.4 | 22 | 14.5 | 146 | 45 | 66 | 3.0 | 07xx C1 | 12xx C1 |
0.075 | 8 | 70.4 | 1072 | 0.4 | 4 | 12.1 | 182 | 55.4 | 101 | 23.5 | 04xx C2 | 15xx C2 |
0.075 | 9 | 57.2 | 927 | 1.9 | 18 | 5.1 | 109 | 33 | 36 | 2.0 | 03xx C1 | |
0.3 | 10 | 55.3 | 538 | 1.2 | 6 | 20.2 | 208 | 50 | 104 | 16.1 | 01xx C1 | 05xx C2 |
0.3 | 11 | 81.7 | 1222 | 3.2 | 39 | 6.9 | 117 | 18.8 | 22 | 0.6 | 01xx C1 | 07xx C1 |
1 | 12 | 76.8 | 1186 | 0.5 | 6 | 6.6 | 124 | 64.4 | 80 | 13.5 | 03xx C1 | 04xx C2 |
1 | 13 | 77.9 | 1033 | 12.5 | 129 | 14.8 | 199 | 51 | 101 | 0.8 | 07xx C1 | |
3 | 14 | 85.2 | 1046 | 3.1 | 32 | 5.7 | 71 | 35.5 | 25 | 0.8 | 03xx C1 | 07xx C1 |
3 | 15 | 51.1 | 631 | 1.9 | 12 | 21.6 | 295 | 45 | 133 | 11.1 | 04xx C2 | 12xx C1 |
3 | 16 | 55 | 911 | 0.6 | 5 | 17.9 | 300 | 43.7 | 131 | 24.0 | 03xx C1 | 04xx C2 |
3 | 17 | 49.7 | 653 | 1.8 | 12 | 21.4 | 287 | 28.8 | 83 | 7.0 | 05xx C2 | |
3 | 18 | 67.7 | 1147 | 0.6 | 7 | 17.5 | 338 | 41 | 139 | 20.1 | 07xx C1 | 15xx C2 |
3 | 19 | 72.5 | 1658 | 1.4 | 23 | 8.9 | 214 | 43.6 | 93 | 4.0 | 02xx C2 | 03xx C1 |
0.0003 | 20 | 72.3 | 664 | 2.3 | 15 | 11.6 | 108 | 22 | 24 | 1.6 | 03xx C1 | 06xx C1 |
0.0003 | 21 | 45.4 | 1137 | 3.5 | 40 | 15.5 | 368 | 78.7 | 290 | 7.3 | 03xx C1 | 04xx C2 |
0.0003 | 22 | 57.8 | 625 | 3.8 | 24 | 6.7 | 72 | 39 | 28 | 1.2 | 05xx C2 | 12xx C1 |
0.003 | 23 | 23.4 | 305 | 2.8 | 9 | 10.2 | 120 | 46.9 | 56 | 6.6 | 04xx C2 | 05xx C2 |
0.075 | 24 | 83.7 | 689 | 0.7 | 5 | 12.4 | 102 | 60.6 | 62 | 12.8 | 01xx C1 | |
0.075 | 25 | 75.5 | 435 | 18.9 | 82 | 17.6 | 95 | 38.7 | 37 | 0.4 | 04xx C2 | 06xx C1 |
0.075 | 26 | 47 | 580 | 5.3 | 31 | 12.4 | 139 | 39.7 | 55 | 1.8 | 01xx C1 | 07xx C1 |
0.3 | 27 | 56.1 | 1120 | 3.4 | 38 | 32.3 | 699 | 39.4 | 275 | 7.2 | 07xx C1 | 12xx C1 |
3 | 28 | 77.1 | 413 | 1.4 | 6 | 13.4 | 73 | 40.2 | 29 | 5.1 | 01xx C1 | 03xx C1 |
1 | 29 | 77.5 | 1652 | 1.6 | 26 | 6.8 | 163 | 48.6 | 79 | 3.0 | 01xx C1 | 16xx C1 |
3 | 30 | 86.3 | 1803 | 2.3 | 41 | 6.4 | 145 | 48.4 | 70 | 1.7 | 04xx C2 | 07xx C2 |
3 | 31 | 45.5 | 446 | 1.6 | 7 | 34.6 | 309 | 20.1 | 62 | 8.7 | 04xx C2 | |
3 | 32 | 60.6 | 546 | 1.1 | 6 | 12.8 | 116 | 48.6 | 56 | 9.4 | 12xx C1 | 16xx C1 |
Mean | 65.9 | 962 | 4 | 34 | 14.7 | 209 | 44.6 | 95 | 6.4 | |||
Median | 69.1 | 919 | 2.3 | 22 | 12.6 | 173 | 44.4 | 77 | 3.3 | |||
SD | 15.1 | 451 | 5.1 | 36 | 8.0 | 130 | 13.9 | 67 | 6.7 |