Adverse events “possibly” or “probably” related to IPH2101 cohort
| Event . | Grade . | 0.075 mg/kg . | 1 mg/kg . | 3 mg/kg . | Total . |
|---|---|---|---|---|---|
| Constitutional | |||||
| Pyrexia | 1 | 0 | 0 | 3 | 3 |
| Fatigue | 1 | 0 | 0 | 2 | 2 |
| Chills | 1 | 0 | 1 | 2 | 3 |
| Flushing | 1 | 0 | 0 | 1 | 1 |
| Headache | 1 | 0 | 1 | 1 | 2 |
| Cardiac | |||||
| Tachycardia | 2 | 1 | 0 | 0 | 1 |
| Gastrointestinal | |||||
| Abdominal pain | 1 | 1 | 0 | 0 | 1 |
| Nausea | 1 | 0 | 1 | 0 | 1 |
| Diarrhea | 1,2 | 0 | 0 | 2 | 2 |
| Laboratory values | |||||
| Neutrophil decrease | 3 | 0 | 0 | 1 | 1 |
| Creatinine increase | 4* | 1* | 0 | 0 | 1* |
| Renal/metabolism | |||||
| Acute renal failure | 3* | 1* | 0 | 0 | 1* |
| Hyperuricemia | 4* | 1* | 0 | 0 | 1* |
| Hyperkalemia | 4* | 1* | 0 | 0 | 1* |
| Event . | Grade . | 0.075 mg/kg . | 1 mg/kg . | 3 mg/kg . | Total . |
|---|---|---|---|---|---|
| Constitutional | |||||
| Pyrexia | 1 | 0 | 0 | 3 | 3 |
| Fatigue | 1 | 0 | 0 | 2 | 2 |
| Chills | 1 | 0 | 1 | 2 | 3 |
| Flushing | 1 | 0 | 0 | 1 | 1 |
| Headache | 1 | 0 | 1 | 1 | 2 |
| Cardiac | |||||
| Tachycardia | 2 | 1 | 0 | 0 | 1 |
| Gastrointestinal | |||||
| Abdominal pain | 1 | 1 | 0 | 0 | 1 |
| Nausea | 1 | 0 | 1 | 0 | 1 |
| Diarrhea | 1,2 | 0 | 0 | 2 | 2 |
| Laboratory values | |||||
| Neutrophil decrease | 3 | 0 | 0 | 1 | 1 |
| Creatinine increase | 4* | 1* | 0 | 0 | 1* |
| Renal/metabolism | |||||
| Acute renal failure | 3* | 1* | 0 | 0 | 1* |
| Hyperuricemia | 4* | 1* | 0 | 0 | 1* |
| Hyperkalemia | 4* | 1* | 0 | 0 | 1* |
Adverse event occurring in the same patient on cohort 4.