Adverse events “possibly” or “probably” related to IPH2101 cohort
Event . | Grade . | 0.075 mg/kg . | 1 mg/kg . | 3 mg/kg . | Total . |
---|---|---|---|---|---|
Constitutional | |||||
Pyrexia | 1 | 0 | 0 | 3 | 3 |
Fatigue | 1 | 0 | 0 | 2 | 2 |
Chills | 1 | 0 | 1 | 2 | 3 |
Flushing | 1 | 0 | 0 | 1 | 1 |
Headache | 1 | 0 | 1 | 1 | 2 |
Cardiac | |||||
Tachycardia | 2 | 1 | 0 | 0 | 1 |
Gastrointestinal | |||||
Abdominal pain | 1 | 1 | 0 | 0 | 1 |
Nausea | 1 | 0 | 1 | 0 | 1 |
Diarrhea | 1,2 | 0 | 0 | 2 | 2 |
Laboratory values | |||||
Neutrophil decrease | 3 | 0 | 0 | 1 | 1 |
Creatinine increase | 4* | 1* | 0 | 0 | 1* |
Renal/metabolism | |||||
Acute renal failure | 3* | 1* | 0 | 0 | 1* |
Hyperuricemia | 4* | 1* | 0 | 0 | 1* |
Hyperkalemia | 4* | 1* | 0 | 0 | 1* |
Event . | Grade . | 0.075 mg/kg . | 1 mg/kg . | 3 mg/kg . | Total . |
---|---|---|---|---|---|
Constitutional | |||||
Pyrexia | 1 | 0 | 0 | 3 | 3 |
Fatigue | 1 | 0 | 0 | 2 | 2 |
Chills | 1 | 0 | 1 | 2 | 3 |
Flushing | 1 | 0 | 0 | 1 | 1 |
Headache | 1 | 0 | 1 | 1 | 2 |
Cardiac | |||||
Tachycardia | 2 | 1 | 0 | 0 | 1 |
Gastrointestinal | |||||
Abdominal pain | 1 | 1 | 0 | 0 | 1 |
Nausea | 1 | 0 | 1 | 0 | 1 |
Diarrhea | 1,2 | 0 | 0 | 2 | 2 |
Laboratory values | |||||
Neutrophil decrease | 3 | 0 | 0 | 1 | 1 |
Creatinine increase | 4* | 1* | 0 | 0 | 1* |
Renal/metabolism | |||||
Acute renal failure | 3* | 1* | 0 | 0 | 1* |
Hyperuricemia | 4* | 1* | 0 | 0 | 1* |
Hyperkalemia | 4* | 1* | 0 | 0 | 1* |
Adverse event occurring in the same patient on cohort 4.