Hematology parameters before and after transplant
| Patient ID . | Donor . | Recipient 6 mo post-BMT . | Chimerism, 6 mo post-BMT . | Bilirubin, pre-BMT . | Bilirubin, 6 mo post-BMT . | Reticulocytes, pre-BMT . | Reticulocytes, 6 mo post-BMT . | Hemoglobin, pre-BMT‡ . | Hemoglobin, 6 mo post-BMT . | Last hemoglobin, days post-BMT . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HbA . | HbS . | HbA . | HbS . | HbF . | |||||||||
| Haploidentical | |||||||||||||
| 1 | NA | NA | 52.4 | 0‡ | < 1.4 | 100 | 1.4 | 0.4 | 184.6 | 130.2 | 10.80 | 11.40 | 13.6 (1087) |
| 3 | 57.9 | 38.4 | 55.1 | 40.4 | 100 | 9.8 | 0.5 | 425.1 | 79.2 | 7.1 | 13.90 | 14.8 (783) | |
| 6 | NA | NA | 94.8 | < 5.0 | 1 | 87 | 1.6 | 0.2 | 234.6 | 45.8 | 10.2 | 11.50 | 11 (722) |
| 7 | 57.9 | 38.9 | 56.5 | 39.2 | < 1.4 | 100 | 0.5 | 0.2 | 54.2 | 40.3 | 8.6 | 11.10 | 9.6 (385) |
| 9 | 55.7 | 39.6 | 23.6 | 60.8 | 11 | 11 | 4.8 | 2.1 | 357 | 232.6 | 9.5 | 6.80 | 6.2 (365) |
| 10 | 57 | 38.2 | 56.1 | 38.7 | 100 | 0.5 | 0.2 | 31.3 | 68.2 | 8.9 | 9.40 | 11.1 (365) | |
| 16 | 100 | 0 | 100 | 100 | 2.2 | 0.2 | 229.4 | 31.8† | 10.3 | 13.00 | 13 (189) | ||
| 17 | 55.6 | 39.7 | 54.2 | 40.8 | 100 | 2.4 | 0.4 | 332.6 | 113.7 | 10.6 | 12.00 | 12 (178) | |
| Median | 1.9 | 0.3 | 232 | 79.2 | 9.85 | 11.45 | 11.55 | ||||||
| HLA-matched | |||||||||||||
| 4 | 55.4 | 40.7 | 55 | 40.3 | 87 | 7.4 | 0.6 | 372.9 | 55.7 | 8.8 | 13.70 | 15 (731) | |
| 11 | 68.8 | 33.1 | 63.2 | 31.4 | 89 | 2.3 | 0.2 | 169.9 | 45.7 | 10.2 | 11.50 | 11.5 (187) | |
| 13 | 55.4 | 40.3 | 60.6 | 28 | 8.5 | 52 | 4.9 | 1.9 | 210.4 | 119.6 | 10.1 | 8.50 | 9.5 (304) |
| Median | 4.9 | 0.6 | 210.4 | 55.7 | 10.10 | 11.50 | 11.5 | ||||||
| Patient ID . | Donor . | Recipient 6 mo post-BMT . | Chimerism, 6 mo post-BMT . | Bilirubin, pre-BMT . | Bilirubin, 6 mo post-BMT . | Reticulocytes, pre-BMT . | Reticulocytes, 6 mo post-BMT . | Hemoglobin, pre-BMT‡ . | Hemoglobin, 6 mo post-BMT . | Last hemoglobin, days post-BMT . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HbA . | HbS . | HbA . | HbS . | HbF . | |||||||||
| Haploidentical | |||||||||||||
| 1 | NA | NA | 52.4 | 0‡ | < 1.4 | 100 | 1.4 | 0.4 | 184.6 | 130.2 | 10.80 | 11.40 | 13.6 (1087) |
| 3 | 57.9 | 38.4 | 55.1 | 40.4 | 100 | 9.8 | 0.5 | 425.1 | 79.2 | 7.1 | 13.90 | 14.8 (783) | |
| 6 | NA | NA | 94.8 | < 5.0 | 1 | 87 | 1.6 | 0.2 | 234.6 | 45.8 | 10.2 | 11.50 | 11 (722) |
| 7 | 57.9 | 38.9 | 56.5 | 39.2 | < 1.4 | 100 | 0.5 | 0.2 | 54.2 | 40.3 | 8.6 | 11.10 | 9.6 (385) |
| 9 | 55.7 | 39.6 | 23.6 | 60.8 | 11 | 11 | 4.8 | 2.1 | 357 | 232.6 | 9.5 | 6.80 | 6.2 (365) |
| 10 | 57 | 38.2 | 56.1 | 38.7 | 100 | 0.5 | 0.2 | 31.3 | 68.2 | 8.9 | 9.40 | 11.1 (365) | |
| 16 | 100 | 0 | 100 | 100 | 2.2 | 0.2 | 229.4 | 31.8† | 10.3 | 13.00 | 13 (189) | ||
| 17 | 55.6 | 39.7 | 54.2 | 40.8 | 100 | 2.4 | 0.4 | 332.6 | 113.7 | 10.6 | 12.00 | 12 (178) | |
| Median | 1.9 | 0.3 | 232 | 79.2 | 9.85 | 11.45 | 11.55 | ||||||
| HLA-matched | |||||||||||||
| 4 | 55.4 | 40.7 | 55 | 40.3 | 87 | 7.4 | 0.6 | 372.9 | 55.7 | 8.8 | 13.70 | 15 (731) | |
| 11 | 68.8 | 33.1 | 63.2 | 31.4 | 89 | 2.3 | 0.2 | 169.9 | 45.7 | 10.2 | 11.50 | 11.5 (187) | |
| 13 | 55.4 | 40.3 | 60.6 | 28 | 8.5 | 52 | 4.9 | 1.9 | 210.4 | 119.6 | 10.1 | 8.50 | 9.5 (304) |
| Median | 4.9 | 0.6 | 210.4 | 55.7 | 10.10 | 11.50 | 11.5 | ||||||
Comparison of hemoglobin variants A, S, and fetal between donors and recipients at the 6-mo posttransplant visit, contrasting it with peripheral blood chimerism in peripheral blood (unsorted) at the same time. Patients 5 and 13 received packed red blood cells within 30 days of this testing. Also comparison of absolute reticulocyte numbers (upper limit of normal is 87 × 103/mm3), hemoglobin (lower limit of normal is 12 g/dL), and total bilirubin (upper limit of normal is 1.2 mg/dL).
Patient 1 has 40.9% hemoglobin C 6 mo post-BMT.
Reticulocyte value obtained 76 days post-BMT.
Pretransplant hemoglobin values reflect transfusions received.