Chimerism values expressed in percentage of donor DNA in peripheral blood
Patient ID . | U Day 30 . | CD3+ day 30 . | U day 60 . | CD3+ day 60 . | U 6 mo . | CD3+ 6 mo . | U 1 y . | CD3+ 1 y . | U most recent . | CD3+ most recent . | Days to most recent chimerism . | Off immunosuppression . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Haploidentical | ||||||||||||
1 | 90 | NA | 100 | NA | 100 | NA | 100 | NA | 100 | NA | 727 | Yes |
2 | 87 | NA | 74 | NA | R | R | R | R | R | R | 79 | Rejected |
3 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 1067 | Yes |
5 | 65 | 0 | 45 | 0 | 10 | 14 | < 5 | 7 | R | R | 1005 | Rejected |
6 | 100 | 89 | > 95 | 100 | 87 | 100 | 89 | > 95 | 92 | 100 | 722 | Yes |
7 | > 95 | 73 | 94 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 385 | Yes |
8 | 0 | 0 | R | R | R | R | R | R | R | R | 48 | Rejected |
9 | 100 | 56 | 41 | 0 | 11 | 9 | 5 | 6 | 5 | 6 | 365 | No |
10 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 356 | Yes |
12 | 91 | 7 | 100 | < 5 | 0 | 0 | R | R | R | R | 171 | Rejected |
14 | 100 | 11 | 0 | 0 | R | R | R | R | R | R | 69 | Rejected |
15 | > 95 | 40 | 100 | 37 | 0 | 0 | R | R | R | R | 154 | Rejected |
16 | 100 | 67 | 100 | 95 | 100 | > 95 | NA | NA | 100 | > 95 | 180 | No |
17 | 100 | 100 | 100 | > 95 | 100 | 100 | NA | NA | 100 | 100 | 205 | Yes |
HLA-matched | ||||||||||||
4 | 78 | 12 | 91 | 10 | 87 | NA | 86 | 52 | 86 | 62 | 979 | No |
11 | 100 | 89 | 91 | 37 | 89 | 35 | 89 | 49 | 89 | 49 | 752 | No |
13 | > 95 | 63 | 95 | 83 | 52 | 65 | 64 | 63 | 64 | 63 | 410 | No |
Patient ID . | U Day 30 . | CD3+ day 30 . | U day 60 . | CD3+ day 60 . | U 6 mo . | CD3+ 6 mo . | U 1 y . | CD3+ 1 y . | U most recent . | CD3+ most recent . | Days to most recent chimerism . | Off immunosuppression . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Haploidentical | ||||||||||||
1 | 90 | NA | 100 | NA | 100 | NA | 100 | NA | 100 | NA | 727 | Yes |
2 | 87 | NA | 74 | NA | R | R | R | R | R | R | 79 | Rejected |
3 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 1067 | Yes |
5 | 65 | 0 | 45 | 0 | 10 | 14 | < 5 | 7 | R | R | 1005 | Rejected |
6 | 100 | 89 | > 95 | 100 | 87 | 100 | 89 | > 95 | 92 | 100 | 722 | Yes |
7 | > 95 | 73 | 94 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 385 | Yes |
8 | 0 | 0 | R | R | R | R | R | R | R | R | 48 | Rejected |
9 | 100 | 56 | 41 | 0 | 11 | 9 | 5 | 6 | 5 | 6 | 365 | No |
10 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 356 | Yes |
12 | 91 | 7 | 100 | < 5 | 0 | 0 | R | R | R | R | 171 | Rejected |
14 | 100 | 11 | 0 | 0 | R | R | R | R | R | R | 69 | Rejected |
15 | > 95 | 40 | 100 | 37 | 0 | 0 | R | R | R | R | 154 | Rejected |
16 | 100 | 67 | 100 | 95 | 100 | > 95 | NA | NA | 100 | > 95 | 180 | No |
17 | 100 | 100 | 100 | > 95 | 100 | 100 | NA | NA | 100 | 100 | 205 | Yes |
HLA-matched | ||||||||||||
4 | 78 | 12 | 91 | 10 | 87 | NA | 86 | 52 | 86 | 62 | 979 | No |
11 | 100 | 89 | 91 | 37 | 89 | 35 | 89 | 49 | 89 | 49 | 752 | No |
13 | > 95 | 63 | 95 | 83 | 52 | 65 | 64 | 63 | 64 | 63 | 410 | No |
U indicates unsorted; CD3+, sorted CD3+ lymphocytes; NA, test was not available at that time (patients 1 and 4) or the patient has not reached the time point for testing (patients 17 and 18); and R, rejection/graft failure (patients 2, 5, 8, 12, 14, and 15).