Basic information about haploidentical and HLA-matched patients and grafts
| Patient ID . | Age, y . | Sex . | Hemoglobin . | Indication for transplantation . | CD3+ dose* . | Nucleated marrow cells* . | CD34+ dose* . | Donor blood . | Recipient blood . |
|---|---|---|---|---|---|---|---|---|---|
| Haploidentical | |||||||||
| 1 | 33 | F | SC | > 10 annual severe pain crisis, alloimmunization, and paroxismal nocturnal haemoglobinuria | 3.29 × 107 | 4.60 × 108 | 4.40 × 106 | O+ | 0+ |
| 2 | 20 | M | SS | > 7 annual severe pain crisis | 4.52 × 107 | 3.41 × 108 | 5.26 × 106 | A+ | A+ |
| 3 | 31 | M | SS | > 4 annual severe pain crisis, osteonecrosis, acute chest syndrome, alloimmunization | 1.69 × 107 | 3.20 × 108 | 8.68 × 106 | B+ | B+ |
| 5 | 22 | M | SS | Monthly severe pain crisis, osteonecrosis | 4.64 × 107 | 4.80 × 108 | 5.22 × 106 | A+ | A+ |
| 6 | 27 | F | SS | > 10 annual severe pain crisis | 3.16 × 107 | 3.40 × 108 | 4.45 × 106 | O+ | O+ |
| 7 | 31 | F | SC | > 10 annual severe pain crisis | 3.55 × 107 | 3.80 × 108 | 7.82 × 106 | O+ | A+ |
| 8 | 16 | M | SS | > 3 annual severe pain crisis and acute chest requiring hospitalization/exchange transfusion | 4.94 × 107 | 4.90 × 108 | 3.66 × 106 | O+ | O+ |
| 9 | 18 | F | SS | > 5 annual severe pain crisis, osteonecrosis, and cerebrovascular disease | 6.59 × 107 | 5.20 × 108 | 4.97 × 106 | A+ | O+ |
| 10 | 25 | F | SS | > 2 annual severe pain crisis (has also lupus nephritis) | 5.20 × 107 | 4.70 × 108 | 5.87 × 106 | O+ | O+ |
| 12 | 42 | F | SS | > 10 annual severe pain crisis, alloimmunization, and acute chest syndrome | 3.83 × 107 | 4.70 × 108 | 2.84 × 106 | B− | B− |
| 14 | 28 | F | SS | > 4 annual severe pain crisis | 2.96 × 107 | 3.60 × 108 | 5.79 × 106 | B− | O− |
| 15 | 20 | F | SS | > 2 annual severe pain crisis, transfusion dependance, acute chest syndrome, and osteonecrosis | 4.06 × 107 | 1.14 × 109 | 4.10 × 106 | O+ | O+ |
| 16 | 21 | F | SS | MRI evidence of cerebrovascular disease, acute chest syndrome, and transfusion dependance | 1.09 × 108 | 1.04 × 109 | 6.02 × 106 | O− | O+ |
| 17 | 15 | M | SS | Moyamoya, transfusion dependence, cerebrovascular disease, > 2 annual severe pain crisis | 1.63 × 108 | 2.16 × 109 | 8.85 × 106 | O+ | O+ |
| HLA-matched | |||||||||
| 4 | 33 | F | SS | > 4 annual severe pain crisis | 2.97 × 107 | 3.60 × 108 | 6.49 × 106 | O+ | O+ |
| 11 | 46 | M | SS | > 10 annual severe pain crisis, acute chest syndrome, and osteonecrosis | 3.67 × 107 | 4.10 × 108 | 4.27 × 106 | O+ | AB+ |
| 13 | 31 | F | SS | > 2 annual severe pain crisis, acute chest syndrome, and osteonecrosis | 3.51 × 107 | 5.00 × 108 | 6.78 × 106 | A+ | A+ |
| Patient ID . | Age, y . | Sex . | Hemoglobin . | Indication for transplantation . | CD3+ dose* . | Nucleated marrow cells* . | CD34+ dose* . | Donor blood . | Recipient blood . |
|---|---|---|---|---|---|---|---|---|---|
| Haploidentical | |||||||||
| 1 | 33 | F | SC | > 10 annual severe pain crisis, alloimmunization, and paroxismal nocturnal haemoglobinuria | 3.29 × 107 | 4.60 × 108 | 4.40 × 106 | O+ | 0+ |
| 2 | 20 | M | SS | > 7 annual severe pain crisis | 4.52 × 107 | 3.41 × 108 | 5.26 × 106 | A+ | A+ |
| 3 | 31 | M | SS | > 4 annual severe pain crisis, osteonecrosis, acute chest syndrome, alloimmunization | 1.69 × 107 | 3.20 × 108 | 8.68 × 106 | B+ | B+ |
| 5 | 22 | M | SS | Monthly severe pain crisis, osteonecrosis | 4.64 × 107 | 4.80 × 108 | 5.22 × 106 | A+ | A+ |
| 6 | 27 | F | SS | > 10 annual severe pain crisis | 3.16 × 107 | 3.40 × 108 | 4.45 × 106 | O+ | O+ |
| 7 | 31 | F | SC | > 10 annual severe pain crisis | 3.55 × 107 | 3.80 × 108 | 7.82 × 106 | O+ | A+ |
| 8 | 16 | M | SS | > 3 annual severe pain crisis and acute chest requiring hospitalization/exchange transfusion | 4.94 × 107 | 4.90 × 108 | 3.66 × 106 | O+ | O+ |
| 9 | 18 | F | SS | > 5 annual severe pain crisis, osteonecrosis, and cerebrovascular disease | 6.59 × 107 | 5.20 × 108 | 4.97 × 106 | A+ | O+ |
| 10 | 25 | F | SS | > 2 annual severe pain crisis (has also lupus nephritis) | 5.20 × 107 | 4.70 × 108 | 5.87 × 106 | O+ | O+ |
| 12 | 42 | F | SS | > 10 annual severe pain crisis, alloimmunization, and acute chest syndrome | 3.83 × 107 | 4.70 × 108 | 2.84 × 106 | B− | B− |
| 14 | 28 | F | SS | > 4 annual severe pain crisis | 2.96 × 107 | 3.60 × 108 | 5.79 × 106 | B− | O− |
| 15 | 20 | F | SS | > 2 annual severe pain crisis, transfusion dependance, acute chest syndrome, and osteonecrosis | 4.06 × 107 | 1.14 × 109 | 4.10 × 106 | O+ | O+ |
| 16 | 21 | F | SS | MRI evidence of cerebrovascular disease, acute chest syndrome, and transfusion dependance | 1.09 × 108 | 1.04 × 109 | 6.02 × 106 | O− | O+ |
| 17 | 15 | M | SS | Moyamoya, transfusion dependence, cerebrovascular disease, > 2 annual severe pain crisis | 1.63 × 108 | 2.16 × 109 | 8.85 × 106 | O+ | O+ |
| HLA-matched | |||||||||
| 4 | 33 | F | SS | > 4 annual severe pain crisis | 2.97 × 107 | 3.60 × 108 | 6.49 × 106 | O+ | O+ |
| 11 | 46 | M | SS | > 10 annual severe pain crisis, acute chest syndrome, and osteonecrosis | 3.67 × 107 | 4.10 × 108 | 4.27 × 106 | O+ | AB+ |
| 13 | 31 | F | SS | > 2 annual severe pain crisis, acute chest syndrome, and osteonecrosis | 3.51 × 107 | 5.00 × 108 | 6.78 × 106 | A+ | A+ |
F indicates female; M, male; SS, hemoglobin SS; and SC, hemoglobin SC.
Cell doses are given per kilogram of ideal body weight of recipient.