Table 3 Etiology of febrile events .... | American Society of Hematology

Table 3

Etiology of febrile events

	Hydroxyurea, N = 96			Placebo, N = 97			Hazard ratio†	P†
	Events	Incidence rate*	Subjects, n (%)	Events	Incidence rate*	Subjects, n (%)	Hazard ratio†	P†
Fever	352	186.2	86 (90)	402	217.4	88 (91)	0.89	.5
Aplastic crisis, parvovirus	4	2.1	4 (4)	4	2.2	4 (4)	0.96	1
Acute osteomyelitis	0	0	0	2	1.1	2 (2)		.2
Bacteremia/sepsis/meningitis	3	1.6	2 (2)	6	3.2	5 (5)	0.40	.3
Viral syndrome	41	21.7	30 (31)	48	26.0	31 (32)	0.92	.7
Gastroenteritis	26	13.8	18 (19)	70	37.9	41 (42)	0.35	< .001
Otitis media	76	40.3	36 (38)	99	53.5	45 (46)	0.73	.2

	Hydroxyurea, N = 96			Placebo, N = 97			Hazard ratio†	P†
	Events	Incidence rate*	Subjects, n (%)	Events	Incidence rate*	Subjects, n (%)	Hazard ratio†	P†
Fever	352	186.2	86 (90)	402	217.4	88 (91)	0.89	.5
Aplastic crisis, parvovirus	4	2.1	4 (4)	4	2.2	4 (4)	0.96	1
Acute osteomyelitis	0	0	0	2	1.1	2 (2)		.2
Bacteremia/sepsis/meningitis	3	1.6	2 (2)	6	3.2	5 (5)	0.40	.3
Viral syndrome	41	21.7	30 (31)	48	26.0	31 (32)	0.92	.7
Gastroenteritis	26	13.8	18 (19)	70	37.9	41 (42)	0.35	< .001
Otitis media	76	40.3	36 (38)	99	53.5	45 (46)	0.73	.2

Per 100 patient-years.

The hazard ratio (hydroxyurea vs placebo) was generated from a Cox model and the P value from the log-rank life test to compare the time to first event between the two treatment groups.