Mutation prevalence in 506 de novo DLBCL patients treated with R-CHOP
| . | No. of patients . | Prevalence . | No. of mutations . | No. of mutation variants . |
|---|---|---|---|---|
| Total patients | 506 | 133 | 99 | |
| Patients with WT-TP53* | 395 | 78% | 1 | 1 |
| Patients with MUT-TP53† | 111 | 22% | 132 | 98 |
| Patients with missense mutations‡ | 92 | 18.2% | 107 | 79 |
| Patients with nonsense mutations | 14 | 2.8% | 14 | 9 |
| Patients with a 2-bp deletion causing reading frame shift | 2 | 0.4% | 2 | 2 |
| Patients with silent mutations§ | 2 | 0.6% | 2 | 2 |
| Patients with a mutation at the splicing sites¶ | 7 | 1.4% | 7 | 6 |
| . | No. of patients . | Prevalence . | No. of mutations . | No. of mutation variants . |
|---|---|---|---|---|
| Total patients | 506 | 133 | 99 | |
| Patients with WT-TP53* | 395 | 78% | 1 | 1 |
| Patients with MUT-TP53† | 111 | 22% | 132 | 98 |
| Patients with missense mutations‡ | 92 | 18.2% | 107 | 79 |
| Patients with nonsense mutations | 14 | 2.8% | 14 | 9 |
| Patients with a 2-bp deletion causing reading frame shift | 2 | 0.4% | 2 | 2 |
| Patients with silent mutations§ | 2 | 0.6% | 2 | 2 |
| Patients with a mutation at the splicing sites¶ | 7 | 1.4% | 7 | 6 |
One DLBCL patient with only 1 silent mutation is also counted as WT-TP53.
Seventeen DLBCL patients had multiple (2-4) mutations.
Fifteen DLBCL patients had 2 missense mutations.
These 2 patients also carried missense mutations.
Four patients carrying a mutation at the splicing site also carried missense mutations.