Table 1 Clinical characteristics and... | American Society of Hematology

Table 1

Clinical characteristics and peripheral blood neutrophil and blast counts for patients treated with quizartinib

Patient	Age/Sex	Karyotype	RL/RF/PR	Baseline ANC	Peak ANC	Days to peak ANC	Baseline PB blasts	Blast count at peak ANC
1	32/M	Diploid	PR	520	3124	63	35	0
2	70/F	Diploid	RL	0	2040	38	8471	0
3	29/F	Diploid	RL	0	280	29	269	0
4	68/M	Diploid	PR	224	3497	63	3556	0
5	55/M	Diploid	RF	0	770	36	57 825	0
6	23/F	Diploid	PR	100	3488	36	9552	0
7	61/M	Diploid	PR	0	2760	36	64 501	0
8	72/M	Diploid	RL	0	720	58	14 062	0
9	54/F	Diploid	RF	40	4500	40	10 370	0
10	64/F	Diploid	PR	0	5290	27	83 808	0
11	56/M	Diploid	PR	0	3560	60	14 204	0
12	33/F	Diploid	RF	330	3350	38	22 272	0
13	62/F	Diploid	RF	50	5540	41	23 409	0
Mean				97	2994	43	24 026	0
14	66/F	Diploid	PR	460	200*	37*	33 642	0*

Patient	Age/Sex	Karyotype	RL/RF/PR	Baseline ANC	Peak ANC	Days to peak ANC	Baseline PB blasts	Blast count at peak ANC
1	32/M	Diploid	PR	520	3124	63	35	0
2	70/F	Diploid	RL	0	2040	38	8471	0
3	29/F	Diploid	RL	0	280	29	269	0
4	68/M	Diploid	PR	224	3497	63	3556	0
5	55/M	Diploid	RF	0	770	36	57 825	0
6	23/F	Diploid	PR	100	3488	36	9552	0
7	61/M	Diploid	PR	0	2760	36	64 501	0
8	72/M	Diploid	RL	0	720	58	14 062	0
9	54/F	Diploid	RF	40	4500	40	10 370	0
10	64/F	Diploid	PR	0	5290	27	83 808	0
11	56/M	Diploid	PR	0	3560	60	14 204	0
12	33/F	Diploid	RF	330	3350	38	22 272	0
13	62/F	Diploid	RF	50	5540	41	23 409	0
Mean				97	2994	43	24 026	0
14	66/F	Diploid	PR	460	200*	37*	33 642	0*

All counts are in cells/mm³. “ANC baseline” refers to the lowest absolute neutrophil count (ANC) during the first week of therapy. “ANC peak” refers to the highest ANC observed after the first week of therapy. “PB blasts baseline” refers to the absolute peripheral blood (PB) blast count at the start of therapy. Mean values are shown for patients 1-13.

RL indicates relapsed; RF, refractory to most recent therapy; and PR, primary refractory (ie, patient was refractory to induction therapy at diagnosis).

For patient 14, the ANC decreased during therapy with quizartinib, but PB blasts were cleared after 1 week.

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