Table 1
Major criteria

  1. Hemoglobin > 18.5 g/dL in men, > 16.5 g/dL in women, or evidence of increased red cell volume*

  2. Presence of JAK2(V617F) or other functionally similar mutation (eg, JAK2 exon 12 mutation)

 
Minor criteria

  1. BM biopsy showing hypercellularity for age with trilineage myeloproliferation

  2. Serum erythropoietin level below the normal reference range

  3. Endogenous erythroid colony formation in vitro

 
Major criteria

  1. Hemoglobin > 18.5 g/dL in men, > 16.5 g/dL in women, or evidence of increased red cell volume*

  2. Presence of JAK2(V617F) or other functionally similar mutation (eg, JAK2 exon 12 mutation)

 
Minor criteria

  1. BM biopsy showing hypercellularity for age with trilineage myeloproliferation

  2. Serum erythropoietin level below the normal reference range

  3. Endogenous erythroid colony formation in vitro

 

The diagnosis of PV requires meeting either both major criteria and 1 minor criterion or the first major criterion and 2 minor criteria.

*

Hemoglobin or hematocrit > 99th percentile of method-specific reference range for age, sex, altitude of residence, or hemoglobin > 17 g/dL in men, 15 g/dL in women if associated with a documented and sustained increase of at least 2 g/dL from a person's baseline value that cannot be attributed to correction of iron deficiency, or elevated red cell mass > 25% above mean normal predicted value.

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