Hemoglobin concentration
| Sample . | MCH, pg/cell . |
|---|---|
| Fetal liver | 22.6 ± 0.3 |
| α0-Thal iPS | 6.2 ± 0.0 |
| β1-Het | 16.6 ± 0.1 |
| β1-Hom | 19.9 ± 0.2 |
| β2-Het | 17.9 ± 0.3 |
| α1-Hom | 21.1 ± 0.4 |
| α2-Hom | 19.5 ± 0.5 |
| Sample . | MCH, pg/cell . |
|---|---|
| Fetal liver | 22.6 ± 0.3 |
| α0-Thal iPS | 6.2 ± 0.0 |
| β1-Het | 16.6 ± 0.1 |
| β1-Hom | 19.9 ± 0.2 |
| β2-Het | 17.9 ± 0.3 |
| α1-Hom | 21.1 ± 0.4 |
| α2-Hom | 19.5 ± 0.5 |
Hemoglobin concentrations (in pictogram per cell) in orthochromatic erythroblasts produced from fetal liver and uncorrected and corrected α0-thal iPSCs. Hemoglobin concentrations (in pictograms/cell) determined by the TMB method in orthochromatic erythroblasts derived from fetal liver and uncorrected and corrected iPSCs with the various constructs integrated (see Table 1 legend).
MCH indicates mean corpuscular hemoglobin; Thal, thalassemia; iPS, induced pluripotent stem; Het, heterozygous insertion; Hom, homozygous insertion; and TMB, tetramethylbenzidine.