Characteristics of the ITP patients enrolled in the study
| Age, y . | Duration of disease, y . | Associated diseases . | Treatment before splenectomy . | Platelet count before (after) splenectomy, 109/mL . | Infection upon splenectomy . | Absolute number of lymphoid nodules (GCs)/3.7 cm2 . |
|---|---|---|---|---|---|---|
| 30 | 19 | Evans syndrome | IvIg, MMF, Prednisol | 2 (22) | None | 42 (0) |
| 64 | 2 | None | Prednisol, azathioiprine, IvIg | 17 (204) | None | 112 (1) |
| 56 | < 1 | Autoimmunodermatitis | Prednisol, IvIg, HC | 21 (110) | None | 46 (0) |
| 77 | < 1 | Colitis ulcerosa | Prednisol, MMF | 29 (443) | Staphylococcal aureus sepsis | 31 (0) |
| 65 | < 1 | NA | NA | NA | NA | 44 (0) |
| 39 | 20 | None | Prednisol, IvIg | 18 (123) | NA | 48 (8) |
| 43 | 8 | None | IvIg, MMF | 3 (410) | S aureus sepsis | 63 (0) |
| 27 | < 1 | Autoimmune thyroidtis | Prednisol, IvIg | 15 (617) | None | 59 (0) |
| 70 | < 1 | NA | NA | NA | NA | 45 (0) |
| 49 | 1 | None | Prednisol, IvIg | 10 (512) | None | 37 (0) |
| 38 | 3 | Evans syndrome | Prednisol | 12 (170) | None | 41 (1) |
| 23 | < 1 | None | Prednisol | 4 (54) | NA | 63 (1) |
| 27 | < 1 | None | Prednisol | 25 (133) | None | 59 (27) |
| 27 | < 1 | None | Prednisol, IvIg | 52 (212) | None | 112 (38) |
| 41 | 13 | Evans syndrome | Prednisol | 13 (78) | None | 43 (0) |
| 44 | < 1 | None | NA | NA | HIV | 33 (1) |
| 39 | 4 | None | Prednisol | 10 (208) | NA | 45 (8) |
| 22 | < 1 | None | Prednisol, IvIg | 11 (74) | None | 38 (0) |
| 24 | < 1 | NA | NA | NA | NA | 26 (0) |
| 18 | < 1 | None | Prednisol | 11 (60) | None | 73 (2) |
| 26 | < 1 | NA | NA | NA | NA | 52 (0) |
| 68 | < 1 | NA | NA | NA | NA | 61 (0) |
| 53 | < 1 | None | Prednisol, vincristin | 2 (500) | None | 57 (0) |
| 69 | < 1 | NA | NA | NA | NA | 54 (2) |
| 31 | < 1 | NA | NA | NA | NA | 64 (16) |
| 22 | 1 | None | Prednisol, IvIg, vincristin azathioprine | 5 (636) | None | 72 (18) |
| 43 | 25 | None | IvIg, anti-D, azathioprine, platelet transfusion | NA (164) | Recurrent infections | NA |
| 71 | 7 | Multiple sclerosis | Mycophenolate, prednisol | < 10 (191) | None | NA |
| 52 | 1 | None | IvIg, anti-D, platelet transfusion | NA (< 10) | None | NA |
| 32 | 3 | None | IvIg, Prednisol, anti-D | NA (320) | None | NA |
| 24 | 2 | None | IvIg, Prednisolone, anti-D, dexamethasone, azathioprine | NA (295) | None | NA |
| Age, y . | Duration of disease, y . | Associated diseases . | Treatment before splenectomy . | Platelet count before (after) splenectomy, 109/mL . | Infection upon splenectomy . | Absolute number of lymphoid nodules (GCs)/3.7 cm2 . |
|---|---|---|---|---|---|---|
| 30 | 19 | Evans syndrome | IvIg, MMF, Prednisol | 2 (22) | None | 42 (0) |
| 64 | 2 | None | Prednisol, azathioiprine, IvIg | 17 (204) | None | 112 (1) |
| 56 | < 1 | Autoimmunodermatitis | Prednisol, IvIg, HC | 21 (110) | None | 46 (0) |
| 77 | < 1 | Colitis ulcerosa | Prednisol, MMF | 29 (443) | Staphylococcal aureus sepsis | 31 (0) |
| 65 | < 1 | NA | NA | NA | NA | 44 (0) |
| 39 | 20 | None | Prednisol, IvIg | 18 (123) | NA | 48 (8) |
| 43 | 8 | None | IvIg, MMF | 3 (410) | S aureus sepsis | 63 (0) |
| 27 | < 1 | Autoimmune thyroidtis | Prednisol, IvIg | 15 (617) | None | 59 (0) |
| 70 | < 1 | NA | NA | NA | NA | 45 (0) |
| 49 | 1 | None | Prednisol, IvIg | 10 (512) | None | 37 (0) |
| 38 | 3 | Evans syndrome | Prednisol | 12 (170) | None | 41 (1) |
| 23 | < 1 | None | Prednisol | 4 (54) | NA | 63 (1) |
| 27 | < 1 | None | Prednisol | 25 (133) | None | 59 (27) |
| 27 | < 1 | None | Prednisol, IvIg | 52 (212) | None | 112 (38) |
| 41 | 13 | Evans syndrome | Prednisol | 13 (78) | None | 43 (0) |
| 44 | < 1 | None | NA | NA | HIV | 33 (1) |
| 39 | 4 | None | Prednisol | 10 (208) | NA | 45 (8) |
| 22 | < 1 | None | Prednisol, IvIg | 11 (74) | None | 38 (0) |
| 24 | < 1 | NA | NA | NA | NA | 26 (0) |
| 18 | < 1 | None | Prednisol | 11 (60) | None | 73 (2) |
| 26 | < 1 | NA | NA | NA | NA | 52 (0) |
| 68 | < 1 | NA | NA | NA | NA | 61 (0) |
| 53 | < 1 | None | Prednisol, vincristin | 2 (500) | None | 57 (0) |
| 69 | < 1 | NA | NA | NA | NA | 54 (2) |
| 31 | < 1 | NA | NA | NA | NA | 64 (16) |
| 22 | 1 | None | Prednisol, IvIg, vincristin azathioprine | 5 (636) | None | 72 (18) |
| 43 | 25 | None | IvIg, anti-D, azathioprine, platelet transfusion | NA (164) | Recurrent infections | NA |
| 71 | 7 | Multiple sclerosis | Mycophenolate, prednisol | < 10 (191) | None | NA |
| 52 | 1 | None | IvIg, anti-D, platelet transfusion | NA (< 10) | None | NA |
| 32 | 3 | None | IvIg, Prednisol, anti-D | NA (320) | None | NA |
| 24 | 2 | None | IvIg, Prednisolone, anti-D, dexamethasone, azathioprine | NA (295) | None | NA |
ITP indicates immune thrombocytopenia; GC, germinal center; NA, not available; MMF, mycophenolate mofetil; HC, healthy control; and prednisol, prednisolon.