Table 3 Relationships between... | American Society of Hematology

Table 3

Relationships between relapse-associated SNPs and pharmacokinetics and pharmacodynamics of antileukemic drugs

SNP information					Association with ALL relapse		Association with asparaginase antibody
SNP ID	Chr	Position	Gene	MAF	P	Risk allele	P	The allele with higher antibody
rs251177	5	141007068	FCHSD1	0.22	6.53 × 10⁻⁵	C	.0053	C
rs6773449	3	26322367		0.03	2.15 × 10⁻⁴	C	.043	C

SNP information					Association with ALL relapse		Association with asparaginase antibody
SNP ID	Chr	Position	Gene	MAF	P	Risk allele	P	The allele with higher antibody
rs251177	5	141007068	FCHSD1	0.22	6.53 × 10⁻⁵	C	.0053	C
rs6773449	3	26322367		0.03	2.15 × 10⁻⁴	C	.043	C

							Association with dexamethasone clearance
							P	The allele with higher clearance
rs6007758	22	46668860		0.01	3.74 × 10⁻⁵	A	.038	A
rs41488548	11	32432060		0.07	6.03 × 10⁻⁵	A	.0052	A
rs10264856	7	87100517	ABCB1; RUNDC3B	0.11	1.84 × 10⁻⁴	T	.029	T
rs4728709	7	87071538	ABCB1	0.11	3.06 × 10⁻⁴	A	.0083	A

							Association with dexamethasone clearance
							P	The allele with higher clearance
rs6007758	22	46668860		0.01	3.74 × 10⁻⁵	A	.038	A
rs41488548	11	32432060		0.07	6.03 × 10⁻⁵	A	.0052	A
rs10264856	7	87100517	ABCB1; RUNDC3B	0.11	1.84 × 10⁻⁴	T	.029	T
rs4728709	7	87071538	ABCB1	0.11	3.06 × 10⁻⁴	A	.0083	A

							Association with MTXPG accumulation
							P	The allele with lower MTXPG
rs6683977	1	66541688	PDE4B	0.45	5.13 × 10⁻⁶	C	.042	C
rs524770	1	66538810	PDE4B	0.42	9.12 × 10⁻⁵	A	.0042	A
rs641262	1	66545937	PDE4B	0.45	9.47 × 10⁻⁵	A	.017	A
rs4265132	7	118907598		0.04	2.01 × 10⁻⁴	T	.047	T
rs16965335	15	51023401		0.03	2.31 × 10⁻⁴	T	.013	T

							Association with MTXPG accumulation
							P	The allele with lower MTXPG
rs6683977	1	66541688	PDE4B	0.45	5.13 × 10⁻⁶	C	.042	C
rs524770	1	66538810	PDE4B	0.42	9.12 × 10⁻⁵	A	.0042	A
rs641262	1	66545937	PDE4B	0.45	9.47 × 10⁻⁵	A	.017	A
rs4265132	7	118907598		0.04	2.01 × 10⁻⁴	T	.047	T
rs16965335	15	51023401		0.03	2.31 × 10⁻⁴	T	.013	T

						Association with MTX clearance
						P	The allele with higher clearance
rs7141601	14	83865815	0.13	1.44 × 10⁻⁴	A	.017	A
rs2613079	4	181846695	0.01	2.02 × 10⁻⁴	A	.023	A
rs12751530	1	41129367	0.17	2.45 × 10⁻⁴	G	.034	G

						Association with MTX clearance
						P	The allele with higher clearance
rs7141601	14	83865815	0.13	1.44 × 10⁻⁴	A	.017	A
rs2613079	4	181846695	0.01	2.02 × 10⁻⁴	A	.023	A
rs12751530	1	41129367	0.17	2.45 × 10⁻⁴	G	.034	G

Chromosomal position is based on hg19. P values indicate the statistical significance of the associations of SNP genotypes with ALL relapse (determined by Fine and Gray hazard regression model) and with pharmacokinetic and pharmacodynamic phenotypes (determined by linear regression).

chr indicates chromosome; MAF, minor allele frequency; MTX, methotrexate; and MTXPG, methotrexate polyglutamate.

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